Federal · SAM.gov · Alexandria, VA

NSF X-Labs Initiative - From Sequence to Function

Federal AgencyIssuing agency·Alexandria, VA·via the SAM.gov Get Opportunities API

97days left

Due Feb 8, 2027·Posted Oct 14, 2026

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AI takeaways

NSF X-Labs teams will build platform technologies that link protein sequence and structure to predictable and controllable biological function for performance within the United States.
Written proposals are due February 8, 2027 at 5:00 p.m. Eastern, with Phase 0 awards of no more than $1,500,000 and Phase 1 awards of no more than $50,000,000 per year.
The National Science Foundation Directorate for Technology, Innovation and Partnerships is soliciting bioengineering teams for the From Sequence to Function topic under OTASO NSF-OTASO-FY26-XLabsInitiative.
Missions may include protein-molecule interaction models, nanoscale protein-based molecular motors, enzyme function platforms, and synthetic cell and genome platforms applied in 2-3 high-utility domains with tailored biosafety and biosecurity plans.
Selected teams begin a 9-month Phase 0 in September 2027, undergo Phase 1 Go/No Go selection in April 2028, and may begin a 24-to-36-month Phase 1 in June 2028.
A Q&A webinar is scheduled November 18, 2026 at 2-3 p.m. Eastern and topic questions are due December 14, 2026 at 5:00 p.m. Eastern for a FAQ document posted to SAM.gov.
Written proposals are limited to 8 single-sided pages plus a separate conflicts statement, submitted as PDFs of 1.5 MB or less via the NSF submission website.
Invited teams submit oral presentation slides, a Phase 0 milestone plan and budget, Senior/Key Personnel disclosures, and collaboration letters and then deliver a virtual oral presentation.
Awards are milestone-based Other Transaction contracts with quarterly payments, requiring team kickoff, data management, IP management, research security, governance, Phase 1 milestone and Phase 1 budget deliverables in Phase 0.
Requirement: Lead organizations must be registered in the Federal Government’s System for Award Management (SAM) with a Unique Entity Identifier prior to submitting a proposal.

Pre-bid: Nov 18
Term: approximately 9 to 12…
Method: Other Transaction (OT)…
Documents: 5 files

These takeaways are AI-generated and may be incomplete or wrong. Always verify every detail against the official documents before you bid.

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Contact the buyer

X-Labs

xlabs@nsf.govEmail

Location:

Alexandria, VA

Open in Maps ↗

Notice

4da70f039bbc4e2fbddce36bc55ab394

NSF-Topic4-FY26-XLabsSequence-to-Function

Method

Solicitation

Duration

approximately 9 to 12 months (Phase 0)

What this bid is asking for

AI-generated

Deliver an 8-page written proposal plus separate conflicts statement as PDFs
If invited, deliver oral slides, Phase 0 milestone plan, personnel disclosures, Phase 0 budget and collaboration letters and present virtually
Execute Phase 0 milestones including kickoff, data, IP, research security and governance plans plus proposed Phase 1 milestones and tiered budgets
Develop a novel platform technology for designing proteins or genomes with predictable function and advance it toward pilot applications

Posted Scope of Work

The National Science Foundation (NSF) Directorate for Technology, Innovation and Partnerships (TIP) announces its intent to solicit Written Proposals for NSF X-Labs teams in the technical domain of bioengineering. This NSF X-Labs announcement is issued under the Other Transactions Agreement Solutions Offering (OTASO), NSF-OTASO-FY26-XLabsInitiative.

Scope, read from the documentsAI-generated

Teams will pioneer and integrate advances in protein design and synthesis, genome assembly, synthetic cells, and experimental functional discovery and validation, potentially using super intelligence to accelerate engineering of designed proteins and synthetic cells, and will develop measurable platform outcomes, prototypes, and 2-3 pilot application projects while executing milestone-based R&D through Phase 0 preparation and Phase 1 scale-up.

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Documents

Download zip

NSF-XLabsOTASO-AttachmentA-WrittenProposalTemplate.pdfPDF

Preview Download

NSF-XLabsOTASO-AttachmentB-COIStatementForm.pdfPDF

Preview Download

NSF-XLabsOTASO-AttachmentC-QuestionSubmissionTemplate.pdfPDF

Preview Download

NSF-XLabsTopicAnnouncement-XLabsSequencetoFunction.pdfPDF

Preview Download

NSF-XLabsOTASO-September16Amendment.pdfPDF

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Questions & answers

AI-generated

How much funding can a team request?

Phase 0 awards are no more than $1,500,000 and Phase 1 awards are no more than $50,000,000 per year.

How do we submit the written proposal?

Proposals must be submitted electronically via the NSF submission website at https://nsfgov.my.site.com/xlabs by 5:00 p.m. Eastern on February 8, 2027.

How many proposals can one organization lead?

An eligible organization can submit a maximum of two Written Proposals per Topic Announcement as a lead organization, and Senior/Key Personnel may be listed on a maximum of one Written Proposal per Topic Announcement.

What happens after the written proposal stage?

NSF invites the most highly qualified teams to submit an Oral Proposal Package due approximately 5 business days prior to scheduled virtual oral presentations.

Full source recordEvery field SAM.gov published, untouched

Hit

4da70f039bbc4e2fbddce36bc55ab394

Type

Code: o
Value: Solicitation

Type

opportunity

Award

Awardee

Title

NSF X-Labs Initiative - From Sequence to Function

R Score

Is Active

Yes

Is Canceled

Publish Date

Oct 14, 2026

Descriptions

Content: <p>The National Science Foundation (NSF) Directorate for Technology, Innovation and Partnerships (TIP) announces its intent to solicit Written Proposals for NSF X-Labs teams in the technical domain of bioengineering. This NSF X-Labs announc
Last Modified Date: Oct 14, 2026

Modified Date

Oct 14, 2026

Response Date

Feb 8, 2027

Modifications

Count: 1

Parent Notice Id

e995137da67647dca05d62b60de441d6

Response Time Zone

America/New_York

Response Date Actual

Feb 8, 2027

Solicitation Number

NSF-Topic4-FY26-XLabsSequence-to-Function

Type

Solicitation

Title

NSF X-Labs Initiative - From Sequence to Function

Active

Yes

Detail

Type

Naics

Code: 541714
Type: primary

Title

NSF X-Labs Initiative - From Sequence to Function

Archive

Date: Feb 23, 2027
Type: auto15

Version

Permissions

IVL

Read: Yes
Create: Yes
Delete: Yes
Update: Yes

Solicitation

Set Aside

NONE

Deadlines

Response: Feb 8, 2027
Response Tz: America/New_York

Organization Id

500210598

Point Of Contact

Type: primary
Email: xlabs@nsf.gov
Full Name: X-Labs

Classification Code

AJ12

Place Of Performance

City

Code: 1180
Name: Alexandria

State

Code: VA
Name: Virginia

Country

Code: USA
Name: UNITED STATES

Solicitation Number

NSF-Topic4-FY26-XLabsSequence-to-Function

Additional Reporting

none

Ui Link

https://sam.gov/opp/4da70f039bbc4e2fbddce36bc55ab394/view

History

Links

Self

Href: https://86samdotgovopportunitiesmodern.prod.apps-internal.prod-iae.bsp.gsa.gov/opps/v2/opportunities/4da70f039bbc4e2fbddce36bc55ab394/history{?postedFrom}
Templated: Yes

History

Index: 2
Title: NSF X-Labs Initiative - From Sequence to Function
Latest: 1
Deleted: 0
Action Date: 2026-10-14T20:55:22.92+00
Action Type: publish
Posted Date: 2026-10-14T20:55:22.915+00
Request Type: modify
Cancel Notice: 0
Archive Notice: 0
Opportunity Id: 4da70f039bbc4e2fbddce36bc55ab394
Procurement Type: o
Solicitation Number: NSF-Topic4-FY26-XLabsSequence-to-Function
Parent Opportunity Id: e995137da67647dca05d62b60de441d6

Index: 1
Title: NSF X-Labs Initiative - From Sequence to Function
Latest: 0
Deleted: 0
Action Date: 2026-10-14T20:46:34.576+00
Action Type: publish
Posted Date: 2026-10-14T20:46:34.572+00
Request Type: submit
Cancel Notice: 0
Archive Notice: 0
Opportunity Id: e995137da67647dca05d62b60de441d6
Procurement Type: o
Solicitation Number: NSF-Topic4-FY26-XLabsSequence-to-Function

Base Type

Solicitation

Notice Id

4da70f039bbc4e2fbddce36bc55ab394

Naics Code

541714

Resources

Attachments

Name: "NSF-XLabsOTASO-AttachmentA-WrittenProposalTemplate.pdf"
Size: 119270
Type: "file"
Mime Type: ".pdf"
File Exists: "1"
Posted Date: "2026-10-14T20:46:34.572+00:00"
Resource Id: "000006cdd2bd4e3a971ca695bc7046b3"
Access Level: "public"
Deleted Flag: "0"
Access Status: "public"
Attachment Id: "416151705b99419aaac33c4ef637661f"
Explicit Access: "0"
Attachment Order: 5
Export Controlled: "0"

Name: "NSF-XLabsOTASO-AttachmentB-COIStatementForm.pdf"
Size: 209693
Type: "file"
Mime Type: ".pdf"
File Exists: "1"
Posted Date: "2026-10-14T20:46:34.572+00:00"
Resource Id: "a104c57a83444ef8919a12a126004052"
Access Level: "public"
Deleted Flag: "0"
Access Status: "public"
Attachment Id: "7254ed299ad6446cb8d1631134f16142"
Explicit Access: "0"
Attachment Order: 4
Export Controlled: "0"

Name: "NSF-XLabsOTASO-AttachmentC-QuestionSubmissionTemplate.pdf"
Size: 127404
Type: "file"
Mime Type: ".pdf"
File Exists: "1"
Posted Date: "2026-10-14T20:46:34.572+00:00"
Resource Id: "be4688510cc9411cbbada67544c26a00"
Access Level: "public"
Deleted Flag: "0"
Access Status: "public"
Attachment Id: "5f67a34b47864526babed11022c7823a"
Explicit Access: "0"
Attachment Order: 3
Export Controlled: "0"

Name: "NSF-XLabsTopicAnnouncement-XLabsSequencetoFunction.pdf"
Size: 167517
Type: "file"
Mime Type: ".pdf"
File Exists: "1"
Posted Date: "2026-10-14T20:46:34.572+00:00"
Resource Id: "02318c6396dc466fbc4989629e3f6e5f"
Access Level: "public"
Deleted Flag: "0"
Access Status: "public"
Attachment Id: "7e1a5f48830948e888edeeb6ae379241"
Explicit Access: "0"
Attachment Order: 2
Export Controlled: "0"

Name: "NSF-XLabsOTASO-September16Amendment.pdf"
Size: 195918
Type: "file"
Mime Type: ".pdf"
File Exists: "1"
Posted Date: "2026-10-14T20:46:34.572+00:00"
Resource Id: "6d077edaa5bf48d8b5de74e83c12c031"
Access Level: "public"
Deleted Flag: "0"
Access Status: "public"
Attachment Id: "fa2e31a6121e488aa97d78198127a739"
Explicit Access: "0"
Attachment Order: 1
Export Controlled: "0"

Opportunity Id

4da70f039bbc4e2fbddce36bc55ab394

Posted Date

Oct 14, 2026

Detail Fetched

Yes

Resource Links

https://sam.gov/api/prod/opps/v3/opportunities/resources/files/000006cdd2bd4e3a971ca695bc7046b3/download?fn=NSF-XLabsOTASO-AttachmentA-WrittenProposalTemplate.pdf, https://sam.gov/api/prod/opps/v3/opportunities/resources/files/a104c57a83444ef8919a12a126004052/download?fn=NSF-XLabsOTASO-AttachmentB-COIStatementForm.pdf, https://sam.gov/api/prod/opps/v3/opportunities/resources/files/be4688510cc9411cbbada67544c26a00/download?fn=NSF-XLabsOTASO-AttachmentC-QuestionSubmissionTemplate.pdf, https://sam.gov/api/prod/opps/v3/opportunities/resources/files/02318c6396dc466fbc4989629e3f6e5f/download?fn=NSF-XLabsTopicAnnouncement-XLabsSequencetoFunction.pdf, https://sam.gov/api/prod/opps/v3/opportunities/resources/files/6d077edaa5bf48d8b5de74e83c12c031/download?fn=NSF-XLabsOTASO-September16Amendment.pdf

History Fetched

Yes

Point Of Contact

Type: primary
Email: xlabs@nsf.gov
Full Name: X-Labs

Description Text

Resources Fetched

Yes

Response Dead Line

Feb 8, 2027

Place Of Performance

City

Code: 1180
Name: Alexandria

State

Code: VA
Name: Virginia

Country

Code: USA
Name: UNITED STATES

Solicitation Number

NSF-Topic4-FY26-XLabsSequence-to-Function

View official postingOpens the original SAM.gov listing in a new tab

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Not finding it?Describe the work in your own words and we’ll search the whole site.Search with AI →

Source: SAM.gov (notice 4da70f039bbc4e2fbddce36bc55ab394), retrieved via the SAM.gov Get Opportunities API. View the official posting, and always confirm requirements and deadlines with the issuing agency.

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Federal · SAM.gov · Alexandria, VA

NSF X-Labs Initiative - From Sequence to Function

Federal AgencyIssuing agency·Alexandria, VA·via the SAM.gov Get Opportunities API

97days left

Due Feb 8, 2027·Posted Oct 14, 2026

Prequalify For BondingBonding Prequal

AI takeaways

NSF X-Labs teams will build platform technologies that link protein sequence and structure to predictable and controllable biological function for performance within the United States.
Written proposals are due February 8, 2027 at 5:00 p.m. Eastern, with Phase 0 awards of no more than $1,500,000 and Phase 1 awards of no more than $50,000,000 per year.
The National Science Foundation Directorate for Technology, Innovation and Partnerships is soliciting bioengineering teams for the From Sequence to Function topic under OTASO NSF-OTASO-FY26-XLabsInitiative.
Missions may include protein-molecule interaction models, nanoscale protein-based molecular motors, enzyme function platforms, and synthetic cell and genome platforms applied in 2-3 high-utility domains with tailored biosafety and biosecurity plans.
Selected teams begin a 9-month Phase 0 in September 2027, undergo Phase 1 Go/No Go selection in April 2028, and may begin a 24-to-36-month Phase 1 in June 2028.
A Q&A webinar is scheduled November 18, 2026 at 2-3 p.m. Eastern and topic questions are due December 14, 2026 at 5:00 p.m. Eastern for a FAQ document posted to SAM.gov.
Written proposals are limited to 8 single-sided pages plus a separate conflicts statement, submitted as PDFs of 1.5 MB or less via the NSF submission website.
Invited teams submit oral presentation slides, a Phase 0 milestone plan and budget, Senior/Key Personnel disclosures, and collaboration letters and then deliver a virtual oral presentation.
Awards are milestone-based Other Transaction contracts with quarterly payments, requiring team kickoff, data management, IP management, research security, governance, Phase 1 milestone and Phase 1 budget deliverables in Phase 0.
Requirement: Lead organizations must be registered in the Federal Government’s System for Award Management (SAM) with a Unique Entity Identifier prior to submitting a proposal.

Pre-bid: Nov 18
Term: approximately 9 to 12…
Method: Other Transaction (OT)…
Documents: 5 files

These takeaways are AI-generated and may be incomplete or wrong. Always verify every detail against the official documents before you bid.

Want to know if you can be bonded for this project? Get prequalified.One free application, soft pull — sized to your work.

Know you can be bonded before you spend a week on the bid
No scramble for a bond at the deadline — it becomes a request form
A good guy letter to show an agency

Prequalify For Bonding →

Contact the buyer

X-Labs

xlabs@nsf.govEmail

Location:

Alexandria, VA

Open in Maps ↗

Notice

4da70f039bbc4e2fbddce36bc55ab394

NSF-Topic4-FY26-XLabsSequence-to-Function

Method

Solicitation

Duration

approximately 9 to 12 months (Phase 0)

What this bid is asking for

AI-generated

Deliver an 8-page written proposal plus separate conflicts statement as PDFs
If invited, deliver oral slides, Phase 0 milestone plan, personnel disclosures, Phase 0 budget and collaboration letters and present virtually
Execute Phase 0 milestones including kickoff, data, IP, research security and governance plans plus proposed Phase 1 milestones and tiered budgets
Develop a novel platform technology for designing proteins or genomes with predictable function and advance it toward pilot applications

Posted Scope of Work

Scope, read from the documentsAI-generated

More science & technology research bids in Virginia, weekly.

We post new science & technology research opportunities in Virginia as agencies publish them. Get them in one email — free, and unsubscribe whenever.

Documents

Download zip

NSF-XLabsOTASO-AttachmentA-WrittenProposalTemplate.pdfPDF

Preview Download

NSF-XLabsOTASO-AttachmentB-COIStatementForm.pdfPDF

Preview Download

NSF-XLabsOTASO-AttachmentC-QuestionSubmissionTemplate.pdfPDF

Preview Download

NSF-XLabsTopicAnnouncement-XLabsSequencetoFunction.pdfPDF

Preview Download

NSF-XLabsOTASO-September16Amendment.pdfPDF

Preview Download

Questions & answers

AI-generated

How much funding can a team request?

Phase 0 awards are no more than $1,500,000 and Phase 1 awards are no more than $50,000,000 per year.

How do we submit the written proposal?

Proposals must be submitted electronically via the NSF submission website at https://nsfgov.my.site.com/xlabs by 5:00 p.m. Eastern on February 8, 2027.

How many proposals can one organization lead?

What happens after the written proposal stage?

NSF invites the most highly qualified teams to submit an Oral Proposal Package due approximately 5 business days prior to scheduled virtual oral presentations.

Full source recordEvery field SAM.gov published, untouched

Hit

4da70f039bbc4e2fbddce36bc55ab394

Type

Code: o
Value: Solicitation

Type

opportunity

Award

Awardee

Title

NSF X-Labs Initiative - From Sequence to Function

R Score

Is Active

Yes

Is Canceled

Publish Date

Oct 14, 2026

Descriptions

Content: <p>The National Science Foundation (NSF) Directorate for Technology, Innovation and Partnerships (TIP) announces its intent to solicit Written Proposals for NSF X-Labs teams in the technical domain of bioengineering. This NSF X-Labs announc
Last Modified Date: Oct 14, 2026

Modified Date

Oct 14, 2026

Response Date

Feb 8, 2027

Modifications

Count: 1

Parent Notice Id

e995137da67647dca05d62b60de441d6

Response Time Zone

America/New_York

Response Date Actual

Feb 8, 2027

Solicitation Number

NSF-Topic4-FY26-XLabsSequence-to-Function

Type

Solicitation

Title

NSF X-Labs Initiative - From Sequence to Function

Active

Yes

Detail

Type

Naics

Code: 541714
Type: primary

Title

NSF X-Labs Initiative - From Sequence to Function

Need a bond for this one? Get prequalified once.

Most Virginia work asks for the two below, and the solicitation documents are where it’s stated. One prequalification covers both — on this bid and the next.

Bid BondUsually 5–10% of your bid

Due with your bid

FreeGet this one →

Performance & Payment BondUsually 100% of the contract

Due after award

Flat 3%Get this one →

$0, forever48-hr responseA-ratedSoft pull

What’s a good guy letter?

A surety’s written statement that it expects to bond you up to a stated amount, subject to final underwriting. It’s what an agency asks to see before they take your bid seriously.

Bonding Directory Get a free bid bond

Not the right RFP for you?

Open opportunities in the same trade and area, with time left to bid

See all Science & Technology Research bids →

Not finding it?Describe the work in your own words and we’ll search the whole site.Search with AI →

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NSF X-Labs Initiative - From Sequence to Function

What this bid is asking for

Posted Scope of Work

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Documents

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Questions & answers

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NSF X-Labs Initiative - From Sequence to Function

What this bid is asking for

Posted Scope of Work

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Documents

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Questions & answers

Need a bond for this one? Get prequalified once.

Not the right RFP for you?