Proactive Health Office (PHO) Mission Office Innovative Solutions Opening (ISO)

The Proactive Health Office (PHO) at ARPA-H is seeking solutions to improve the healthspan and health outcomes of Americans prior to the onset of disease and/or the development of diminished quality of life from illness. Specifically, PHO hypothesizes that 1) population-level improvements in access to and uptake of disease prevention and wellness-promoting behaviors and 2) development of novel early-detection methods and prophylactic interventions could drastically improve the health of American throughout their lives, and 3) that system level innovations are required for delivery of proactive health effectively.

• Solution summary submissions must be submitted to: https://solutions.arpa-h.gov

• Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/

• Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/

Amendment 4 is effective immediately; however, if an entity has previously submitted a Solution Summary and a proposal, no action is required related to changes described in the amendment. If only a Solution Summary has been submitted; any future proposal must comply with this amendment.

Amendment 04 includes the following changes:

• Updated Administrative and National Policy Requirements document (Note other Bundle of Attachment documents are unchanged)

• Minor changes throughout the ISO, including, but not limited to: Updating the name from ARPA-H Solution Submission Portal to ARPA-H Solutions Site, notation in paragraph 2.3, and revised language in Section 6.1 Research Security Disclosures to align with the updated Bundle of Attachments document.