Selective Harnessing of Intrinsic Neuroplasticity Engineering (SHINE)

The SHINE program seeks to design, develop, and demonstrate functional biological, chemical, or physical prototype systems capable of inducing circuit-selective neuroplasticity. The work involves two technical tracks: Track A focuses on clinical-ready prototype systems with a pathway toward human application, while Track B focuses on high-risk, proof-of-concept prototype platforms. Performers must complete five fixed payable milestones over an 18-month period, including experimental baseline validation, selective substrate localization, localized target engagement verification, circuit-selective neuroplasticity demonstration, and intervention prototype finalization. The program requires demonstrating intervention selectivity (3:1 ratio target vs. off-target), biological target engagement (≥2-fold increase), and quantifiable change in neuroplasticity (effect size >0.6).