Federal · SAM.gov · Washington, DC

Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS)

Department of Health and Human ServicesIssuing agency·Washington, DC·via the SAM.gov Get Opportunities API

52days left

Due Nov 30, 2026·Posted Sep 30, 2026

Prequalify For BondingBonding Prequal

AI takeaways

The Advanced Research Projects Agency for Health (ARPA-H) is soliciting proposals for the Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS) Program to develop persistent, multi-arm adaptive platform trials that shorten clinical drug development.
The place of performance is DC, and the solicitation number is ARPA-H-SOL-26-164.
Key dates: Informational Webinar on 15 OCT 2026, Proposers' Day on 6 and 9 NOV 2026, Questions Due on 2 NOV 2026, Solution Summary Due on 30 NOV 2026, and Solution Pitch Package Due on 22 JAN 2027.
ARPA-H anticipates multiple Other Transaction Agreement awards will result from this opportunity.
The program combines three integrated Technical Areas: TA1 (Phaseless Design Engine), TA2 (Continuous Inference), and TA3 (Agentic Operations).
Each Core Platform Team must propose at least three drug or biologic intervention arms, with at least two not approved for any indication and at least one with no prior human data.
The program is a five-year effort with Stage I (Platform and Capability Buildout, 24 months) and Stage II (Capability Validation and Deployment, 36 months).
All questions must be submitted to SURPASS@ARPA-H.GOV.
Requirement: Proposers must have initiated registration in SAM and possess a Unique Entity Identifier (UEI) for their Solution Pitch package to be found conforming.
Requirement: Proposers must have an active registration in SAM.gov to be eligible for an Award with ARPA-H.

Pre-bid: Oct 15
Term: five-year program
Method: Solicitation
Documents: 6 files

These takeaways are AI-generated and may be incomplete or wrong. Always verify every detail against the official documents before you bid.

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Contact the buyer

The SURPASS Team

surpass@arpa-h.govEmail

Location:

DC 20005

Open in Maps ↗

Notice

11128fed4f044b68a9185dada11c90d9

ARPA-H-SOL-26-164

Method

Solicitation

Duration

five-year program

What this bid is asking for

AI-generated

Submit a Solution Summary by 30 NOV 2026 describing the proposed disease area, drug/biologic arms, sponsors, platform trial design, and innovations across TA1, TA2, and TA3.
If encouraged, submit a Solution Pitch Package by 22 JAN 2027 including a pitch deck, Gantt chart, preliminary master protocol, description of in silico and AI models, scope of work, and cost workbook.
Participate in a mandatory virtual Solution Pitch (estimated early February 2027) with a 15-minute presentation and up to 45 minutes of questions.
Demonstrate the ability to establish a multi-site clinical network, open the first site to enrollment by program year 2, and sustain the platform for approximately a decade after ARPA-H funding ends.

Posted Scope of Work

Interested parties are invited to review the attached Solicitation (ARPA-H-SOL-26-164) and associated attachments.

As detailed in Special Notice ARPA-H-SN-26-164, ARPA-H will host an informational webinar on 15 OCT 2026 and a 2-day Proposers’ Day on 6 and 9 NOV 2026 in support of SURPASS.

All questions related to SURPASS should be submitted to SURPASS@ARPA-H.GOV.

Scope, read from the documentsAI-generated

The SURPASS program aims to develop, integrate, and clinically validate capabilities for persistent, multi-arm adaptive platform trials. Core Platform Teams will establish a platform trial in a single disease area, including a master protocol, shared controls, seamless/phaseless design, and end-to-end clinical operations. Each team must propose at least three drug or biologic intervention arms, include at least six clinical sites by program end, and integrate three Technical Areas: TA1 (simulation-based design engine with in silico capabilities), TA2 (continuous-inference and adaptation-validity engine), and TA3 (AI-enabled operational systems). The program spans five years across two stages: Stage I (24 months) for platform and capability buildout, and Stage II (36 months) for capability validation and deployment.

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Documents

Download zip

SOL_26_164_SURPASS ISO.pdfPDF

Preview Download

SOL_26_164_Attach 1_SOW Template.docxDOCX

Preview Download

SOL_26_164_Attach 2_Cost Workbook.xlsxXLSX

Document 4Link

Document 5Link

Document 6Link

Questions & answers

AI-generated

What is the submission deadline for the Solution Summary?

The Solution Summary Due Date (ISO Closing Date) is 30 NOV 2026 by 5pm ET.

How do I submit questions about this solicitation?

All questions regarding this ISO must be submitted to SURPASS@ARPA-H.GOV.

What type of awards are anticipated?

ARPA-H anticipates multiple Other Transaction Agreement awards will result from this opportunity.

Is there a pre-bid conference or webinar?

ARPA-H will host an informational webinar on 15 OCT 2026 and a 2-day Proposers’ Day on 6 and 9 NOV 2026 in support of SURPASS.

Full source recordEvery field SAM.gov published, untouched

Hit

11128fed4f044b68a9185dada11c90d9

Type

Code: o
Value: Solicitation

Type

opportunity

Award

Awardee

Title

Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS)

R Score

Is Active

Yes

Is Canceled

Publish Date

Sep 30, 2026

Descriptions

Content: <p>The Advanced Research Projects Agency for Health (ARPA-H) posts this solicitation in support of its Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS) Program. ARPA-H anticipates multiple Other Transaction Agreement a
Last Modified Date: Sep 30, 2026

Modified Date

Sep 30, 2026

Response Date

Nov 30, 2026

Modifications

Count: 0

Response Time Zone

America/New_York

Response Date Actual

Nov 30, 2026

Solicitation Number

ARPA-H-SOL-26-164

Organization Hierarchy

Code

7500

Name

HEALTH AND HUMAN SERVICES, DEPARTMENT OF

Type

DEPARTMENT

Level

Status

active

Address

Zip: "20201"
City: "Washington"
State: "DC"
Country: "US"
Street Address: "Hubert H. Humphrey Building 200 Independence Avenue, SW "

Organization Id

100004222

Code

7529

Name

NATIONAL INSTITUTES OF HEALTH

Type

AGENCY

Level

Status

active

Address

Zip: "20892"
City: "Bethesda"
State: "MD"
Country: "US"
Street Address: "3100 Center Drive Room 1B59"

Organization Id

100019747

Code

75N992

Name

NIH ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)

Type

OFFICE

Level

Status

active

Address

Zip: "208920004"
City: "Bethesda"
State: "MD"
Country: "USA"
Street Address: "BG NIHBC 01 Room 228"
Street Address2: "1 Center Drive"

Organization Id

500183629

Org

Cgac

075

Code

75N992

Name

ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)

Type

OFFICE

Level

L1 Name

HEALTH AND HUMAN SERVICES, DEPARTMENT OF

L2 Name

NATIONAL INSTITUTES OF HEALTH

L3 Name

ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)

Org Key

500183629

Aac Code

75N992

Fpds Code

7529

L1 Org Key

100004222

L2 Org Key

100019747

Created By

krystina.womack@hhs.gov

Fpds Org Id

75N992

Mod Status

ACTIVE

Parent Org

NATIONAL INSTITUTES OF HEALTH

Short Name

ARPA-H

Start Date

Jul 1, 2022

Created Date

Jul 5, 2022

L1 Short Name

HHS

Has Contracts

Yes

Org Addresses

City: Washington
Type: M
State: DC
Org Key: 500183629
Zipcode: 20005
Created By: jacob.kuruvilla@hhs.gov
Mod Status: active
Address Key: 501053347
Country Code: USA
Created Date: Sep 23, 2024
Street Address: 1301 K Street NW
Last Modified By: jacob.kuruvilla@hhs.gov
Street Address 2: Suite 1200 West
Last Modified Date: Sep 23, 2024

Parent Org Key

100019747

Code Hierarchy

7500.7529.75N992

Full Parent Path

100004222.100019747.500183629

Last Modified By

jacob.kuruvilla@hhs.gov

Org Office Types

Org Key: 500183629
Position: 3
Is Latest: Yes
Office Id: 2286011
Created By: krystina.womack@hhs.gov
Mod Status: Yes
Start Date: Jul 1, 2022
Office Type: 1
Created Date: Jul 5, 2022
Office Type Id: 1
Last Modified By: krystina.womack@hhs.gov
Office Type Name: CONTRACT FUNDING
Last Modified Date: Jul 5, 2022

Org Key: 500183629
Position: 4
Is Latest: Yes
Office Id: 2342843
Created By: jacob.kuruvilla@hhs.gov
Mod Status: Yes
Start Date: Jul 1, 2022
Office Type: 5
Created Date: Sep 13, 2023
Office Type Id: 5
Last Modified By: jacob.kuruvilla@hhs.gov
Office Type Name: FINANCIAL ASSISTANCE FUNDING
Last Modified Date: Sep 13, 2023

Org Key: 500183629
Position: 1
Is Latest: Yes
Office Id: 2286010
Created By: krystina.womack@hhs.gov
Mod Status: Yes
Start Date: Jul 1, 2022
Office Type: 2
Created Date: Jul 5, 2022
Office Type Id: 2
Last Modified By: krystina.womack@hhs.gov
Office Type Name: CONTRACT AWARDS
Last Modified Date: Jul 5, 2022

Org Key: 500183629
Position: 2
Is Latest: Yes
Office Id: 2342842
Created By: jacob.kuruvilla@hhs.gov
Mod Status: Yes
Start Date: Jul 1, 2022
Office Type: 3
Created Date: Sep 13, 2023
Office Type Id: 3
Last Modified By: jacob.kuruvilla@hhs.gov
Office Type Name: FINANCIAL ASSISTANCE AWARDS
Last Modified Date: Sep 13, 2023

Last Modified Date

Oct 2, 2024

Full Parent Path Name

HEALTH AND HUMAN SERVICES, DEPARTMENT OF.NATIONAL INSTITUTES OF HEALTH.ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)

Type

Solicitation

Title

Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS)

Active

Yes

Detail

Type

Naics

Code: 541714
Type: primary

Title

Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS)

Need a bond for this one? Get prequalified once.

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Bid BondUsually 5–10% of your bid

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FreeGet this one →

Performance & Payment BondUsually 100% of the contract

Due after award

Flat 3%Get this one →

$0, forever48-hr responseA-ratedSoft pull

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Source: SAM.gov (notice 11128fed4f044b68a9185dada11c90d9), retrieved via the SAM.gov Get Opportunities API. View the official posting, and always confirm requirements and deadlines with the issuing agency.

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Federal · SAM.gov · Washington, DC

Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS)

Department of Health and Human ServicesIssuing agency·Washington, DC·via the SAM.gov Get Opportunities API

52days left

Due Nov 30, 2026·Posted Sep 30, 2026

Prequalify For BondingBonding Prequal

AI takeaways

The Advanced Research Projects Agency for Health (ARPA-H) is soliciting proposals for the Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS) Program to develop persistent, multi-arm adaptive platform trials that shorten clinical drug development.
The place of performance is DC, and the solicitation number is ARPA-H-SOL-26-164.
Key dates: Informational Webinar on 15 OCT 2026, Proposers' Day on 6 and 9 NOV 2026, Questions Due on 2 NOV 2026, Solution Summary Due on 30 NOV 2026, and Solution Pitch Package Due on 22 JAN 2027.
ARPA-H anticipates multiple Other Transaction Agreement awards will result from this opportunity.
The program combines three integrated Technical Areas: TA1 (Phaseless Design Engine), TA2 (Continuous Inference), and TA3 (Agentic Operations).
Each Core Platform Team must propose at least three drug or biologic intervention arms, with at least two not approved for any indication and at least one with no prior human data.
The program is a five-year effort with Stage I (Platform and Capability Buildout, 24 months) and Stage II (Capability Validation and Deployment, 36 months).
All questions must be submitted to SURPASS@ARPA-H.GOV.
Requirement: Proposers must have initiated registration in SAM and possess a Unique Entity Identifier (UEI) for their Solution Pitch package to be found conforming.
Requirement: Proposers must have an active registration in SAM.gov to be eligible for an Award with ARPA-H.

Pre-bid: Oct 15
Term: five-year program
Method: Solicitation
Documents: 6 files

These takeaways are AI-generated and may be incomplete or wrong. Always verify every detail against the official documents before you bid.

Want to know if you can be bonded for this project? Get prequalified.One free application, soft pull — sized to your work.

Know you can be bonded before you spend a week on the bid
No scramble for a bond at the deadline — it becomes a request form
A good guy letter to show an agency

Prequalify For Bonding →

Contact the buyer

The SURPASS Team

surpass@arpa-h.govEmail

Location:

DC 20005

Open in Maps ↗

Notice

11128fed4f044b68a9185dada11c90d9

ARPA-H-SOL-26-164

Method

Solicitation

Duration

five-year program

What this bid is asking for

AI-generated

Submit a Solution Summary by 30 NOV 2026 describing the proposed disease area, drug/biologic arms, sponsors, platform trial design, and innovations across TA1, TA2, and TA3.
If encouraged, submit a Solution Pitch Package by 22 JAN 2027 including a pitch deck, Gantt chart, preliminary master protocol, description of in silico and AI models, scope of work, and cost workbook.
Participate in a mandatory virtual Solution Pitch (estimated early February 2027) with a 15-minute presentation and up to 45 minutes of questions.
Demonstrate the ability to establish a multi-site clinical network, open the first site to enrollment by program year 2, and sustain the platform for approximately a decade after ARPA-H funding ends.

Posted Scope of Work

Interested parties are invited to review the attached Solicitation (ARPA-H-SOL-26-164) and associated attachments.

As detailed in Special Notice ARPA-H-SN-26-164, ARPA-H will host an informational webinar on 15 OCT 2026 and a 2-day Proposers’ Day on 6 and 9 NOV 2026 in support of SURPASS.

All questions related to SURPASS should be submitted to SURPASS@ARPA-H.GOV.

Scope, read from the documentsAI-generated

More science & technology research bids in Washington, DC, weekly.

We post new science & technology research opportunities in Washington, DC as agencies publish them. Get them in one email — free, and unsubscribe whenever.

Documents

Download zip

SOL_26_164_SURPASS ISO.pdfPDF

Preview Download

SOL_26_164_Attach 1_SOW Template.docxDOCX

Preview Download

SOL_26_164_Attach 2_Cost Workbook.xlsxXLSX

Document 4Link

Document 5Link

Document 6Link

Questions & answers

AI-generated

What is the submission deadline for the Solution Summary?

The Solution Summary Due Date (ISO Closing Date) is 30 NOV 2026 by 5pm ET.

How do I submit questions about this solicitation?

All questions regarding this ISO must be submitted to SURPASS@ARPA-H.GOV.

What type of awards are anticipated?

ARPA-H anticipates multiple Other Transaction Agreement awards will result from this opportunity.

Is there a pre-bid conference or webinar?

ARPA-H will host an informational webinar on 15 OCT 2026 and a 2-day Proposers’ Day on 6 and 9 NOV 2026 in support of SURPASS.

Full source recordEvery field SAM.gov published, untouched

Hit

11128fed4f044b68a9185dada11c90d9

Type

Code: o
Value: Solicitation

Type

opportunity

Award

Awardee

Title

Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS)

R Score

Is Active

Yes

Is Canceled

Publish Date

Sep 30, 2026

Descriptions

Content: <p>The Advanced Research Projects Agency for Health (ARPA-H) posts this solicitation in support of its Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS) Program. ARPA-H anticipates multiple Other Transaction Agreement a
Last Modified Date: Sep 30, 2026

Modified Date

Sep 30, 2026

Response Date

Nov 30, 2026

Modifications

Count: 0

Response Time Zone

America/New_York

Response Date Actual

Nov 30, 2026

Solicitation Number

ARPA-H-SOL-26-164

Organization Hierarchy

Code

7500

Name

HEALTH AND HUMAN SERVICES, DEPARTMENT OF

Type

DEPARTMENT

Level

Status

active

Address

Zip: "20201"
City: "Washington"
State: "DC"
Country: "US"
Street Address: "Hubert H. Humphrey Building 200 Independence Avenue, SW "

Organization Id

100004222

Code

7529

Name

NATIONAL INSTITUTES OF HEALTH

Type

AGENCY

Level

Status

active

Address

Zip: "20892"
City: "Bethesda"
State: "MD"
Country: "US"
Street Address: "3100 Center Drive Room 1B59"

Organization Id

100019747

Code

75N992

Name

NIH ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)

Type

OFFICE

Level

Status

active

Address

Zip: "208920004"
City: "Bethesda"
State: "MD"
Country: "USA"
Street Address: "BG NIHBC 01 Room 228"
Street Address2: "1 Center Drive"

Organization Id

500183629

Org

Cgac

075

Code

75N992

Name

ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)

Type

OFFICE

Level

L1 Name

HEALTH AND HUMAN SERVICES, DEPARTMENT OF

L2 Name

NATIONAL INSTITUTES OF HEALTH

L3 Name

ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)

Org Key

500183629

Aac Code

75N992

Fpds Code

7529

L1 Org Key

100004222

L2 Org Key

100019747

Created By

krystina.womack@hhs.gov

Fpds Org Id

75N992

Mod Status

ACTIVE

Parent Org

NATIONAL INSTITUTES OF HEALTH

Short Name

ARPA-H

Start Date

Jul 1, 2022

Created Date

Jul 5, 2022

L1 Short Name

HHS

Has Contracts

Yes

Org Addresses

City: Washington
Type: M
State: DC
Org Key: 500183629
Zipcode: 20005
Created By: jacob.kuruvilla@hhs.gov
Mod Status: active
Address Key: 501053347
Country Code: USA
Created Date: Sep 23, 2024
Street Address: 1301 K Street NW
Last Modified By: jacob.kuruvilla@hhs.gov
Street Address 2: Suite 1200 West
Last Modified Date: Sep 23, 2024

Parent Org Key

100019747

Code Hierarchy

7500.7529.75N992

Full Parent Path

100004222.100019747.500183629

Last Modified By

jacob.kuruvilla@hhs.gov

Org Office Types

Org Key: 500183629
Position: 3
Is Latest: Yes
Office Id: 2286011
Created By: krystina.womack@hhs.gov
Mod Status: Yes
Start Date: Jul 1, 2022
Office Type: 1
Created Date: Jul 5, 2022
Office Type Id: 1
Last Modified By: krystina.womack@hhs.gov
Office Type Name: CONTRACT FUNDING
Last Modified Date: Jul 5, 2022

Org Key: 500183629
Position: 4
Is Latest: Yes
Office Id: 2342843
Created By: jacob.kuruvilla@hhs.gov
Mod Status: Yes
Start Date: Jul 1, 2022
Office Type: 5
Created Date: Sep 13, 2023
Office Type Id: 5
Last Modified By: jacob.kuruvilla@hhs.gov
Office Type Name: FINANCIAL ASSISTANCE FUNDING
Last Modified Date: Sep 13, 2023

Org Key: 500183629
Position: 1
Is Latest: Yes
Office Id: 2286010
Created By: krystina.womack@hhs.gov
Mod Status: Yes
Start Date: Jul 1, 2022
Office Type: 2
Created Date: Jul 5, 2022
Office Type Id: 2
Last Modified By: krystina.womack@hhs.gov
Office Type Name: CONTRACT AWARDS
Last Modified Date: Jul 5, 2022

Org Key: 500183629
Position: 2
Is Latest: Yes
Office Id: 2342842
Created By: jacob.kuruvilla@hhs.gov
Mod Status: Yes
Start Date: Jul 1, 2022
Office Type: 3
Created Date: Sep 13, 2023
Office Type Id: 3
Last Modified By: jacob.kuruvilla@hhs.gov
Office Type Name: FINANCIAL ASSISTANCE AWARDS
Last Modified Date: Sep 13, 2023

Last Modified Date

Oct 2, 2024

Full Parent Path Name

HEALTH AND HUMAN SERVICES, DEPARTMENT OF.NATIONAL INSTITUTES OF HEALTH.ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)

Type

Solicitation

Title

Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS)

Active

Yes

Detail

Type

Naics

Code: 541714
Type: primary

Title

Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS)

Need a bond for this one? Get prequalified once.

Most Washington, DC work asks for the two below, and the solicitation documents are where it’s stated. One prequalification covers both — on this bid and the next.

Bid BondUsually 5–10% of your bid

Due with your bid

FreeGet this one →

Performance & Payment BondUsually 100% of the contract

Due after award

Flat 3%Get this one →

$0, forever48-hr responseA-ratedSoft pull

What’s a good guy letter?

A surety’s written statement that it expects to bond you up to a stated amount, subject to final underwriting. It’s what an agency asks to see before they take your bid seriously.

Bonding Directory Get a free bid bond

Not the right RFP for you?

Open opportunities in the same trade and area, with time left to bid

See all Science & Technology Research bids →

Not finding it?Describe the work in your own words and we’ll search the whole site.Search with AI →

Prequalify For Bondingknow you’re bondable · no bond scramble Bid bond

Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS)

What this bid is asking for

Posted Scope of Work

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Documents

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Questions & answers

Need a bond for this one? Get prequalified once.

Not the right RFP for you?

Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS)

What this bid is asking for

Posted Scope of Work

More science & technology research bids in Washington, DC, weekly.

Documents

Sign up for a Light RFP account to download documents

Questions & answers

Need a bond for this one? Get prequalified once.

Not the right RFP for you?