The Advanced Research Projects Agency for Health (ARPA-H) Comprehensive Organ System Modeling in Outer Space (COSMOS) Initiative aims to definitively prove or disprove if exposure to microgravity in Low Earth Orbit (LEO) truly accelerates tissue aging across brain, cardiac, uterine, and kidney tissue types and across several adult age brackets. Provided Tissue Aging Rate in Space (TARIS) exceeds Tissue Aging Rate on Earth (TAROE) at a rate that exceeds the on Earth breakeven cost for new drug R&D, COSMOS will create a first-in-class platform for fully autonomous, high-throughput drug screening in LEO that would be more cost effective and faster than new drug R&D on Earth.
ARPA-H anticipates multiple Other Transaction awards resulting from this announcement.
Interested parties are invited to download and review the attached COSMOS Innovative Solutions Opening (ISO) ARPA-H-SOL-26-165
Amendment 01 – 17 September 2026: This amendment includes updated hyperlinks and information on the updated Solutions summary portal.
Questions and Answers – 21 September 2026: This Q&A is provided for informational purposes only and does not amend the solicitation. All other questions are due by 23 September 2026 at 5:00PM ET.
Amendment 02 – 23 September 2026: This amendment includes updates to Section 3, COSMOS Details; Section 4, Mandatory Experimental Design; as well as Correction to Figure 2.
Performers will establish and validate microphysiological systems (MPSs) and organoids for one selected organ (brain, heart, uterus, or kidney) using cells from healthy donors across three age brackets (30±2, 45±2, 60±2 years). Phase I requires a terrestrial-only study (≥225 MPSs, ≥75 organoids) and a LEO/Terrestrial Twin Study (288 MPSs and 96 organoids, matched 144/48 in flight and 144/48 on ground). Experiments in LEO will be fully autonomous. Phase II will use the tissues showing TARIS > TAROE to develop disease models and conduct drug screening in partnership with a Fortune 100 biopharmaceutical company. The work includes creating in silico aging models, data management, and commercialization planning.
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"20201""Washington""DC""US""Hubert H. Humphrey Building 200 Independence Avenue, SW ""20892""Bethesda""MD""US""3100 Center Drive Room 1B59""208920004""Bethesda""MD""USA""BG NIHBC 01 Room 228""1 Center Drive""ARPA-H-SOL-26-165_COSMOS_ISO_Amendment 02.pdf"1776878"file"".pdf""1""2026-09-23T16:30:01.564+00:00""59336b7374004766a1e3414ebf00ec67""public""0""public""57f2e7eb552c4e03831565068ffcde2b""0"12"0""ARPA-H-SOL-26-165_COSMOS_QA_Set_1_2026-09-21.pdf"27954"file"".pdf""1""2026-09-21T23:06:42.883+00:00""fcefbbb411f64e4c8fb6e43618d66b50""public""0""public""31d1a93a2e174a4eb4ff8a87b836df5f""0"11"0""ARPA-H-SOL-26-165_COSMOS_ISO_Amendment 01.pdf"1933730"file"".pdf""1""2026-09-17T15:51:50.826+00:00""86156dc78b2844828189f21a876eb1f0""public""2026-09-23T16:30:01.564+00:00""1""public""94e22b1c88044a4fbbd10ff8006362fd""0"10"0""2026-09-23T16:30:01.564+00:00""Attachment E_COSMOS Administrative and National Policy Requirements.docx"97684"file"".docx""1""2026-09-16T19:17:13.811+00:00""4249cfb685fc45908b02847b13094000""public""0""public""ab47a580cc704783be0430d3bcf69f9b""0"8"0""ATTACHMENT A.1_Technical & Management Proposal Model (VOL I).docx"56227"file"".docx""1""2026-09-16T19:17:13.811+00:00""e1208b36c5354eb8a9205ef41b35730c""public""0""public""56dff753e4804c5a9caf3230d3a5593a""0"7"0""Attachment D_COSMOS Cost Proposal Template.xlsx"149024"file"".xlsx""1""2026-09-16T19:17:13.811+00:00""3bffd79ec8644ff5a478dc5e5a60e0c2""public""0""public""a1216fae8518402e9022f4352d90bb5e""0"6"0""ATTACHMENT A.2_Task Description Document Model.docx"43509"file"".docx""1""2026-09-16T19:17:13.811+00:00""42c5c638fedb4caca948f380a393f560""public""0""public""359d6726e67f47ccab038fe40d2410da""0"5"0""ATTACHMENT B_COSMOS Eligibility and Conformance Certification Sheet.docx"36557"file"".docx""1""2026-09-16T19:17:13.811+00:00""0bcc046159444a71985b08eb41da892c""public""0""public""e5ad742304424ac692d7687bbe2093aa""0"4"0""ATTACHMENT C COSMOS Schedule.xlsx"20898"file"".xlsx""1""2026-09-16T19:17:13.811+00:00""bb7c5c3bce3a4ebf9842cedc745abade""public""0""public""918e1af815b849109b7bf79beb53dea2""0"3"0""ATTACHMENT A.3_COSMOS Milestone and Payment Table.xlsx"22307"file"".xlsx""1""2026-09-16T19:17:13.811+00:00""f0acc10b4dcb42babcd3c651e8ee1469""public""0""public""18d118f830a04ccba561346eab004c5c""0"2"0"Most Washington, DC work asks for the two below, and the solicitation documents are where it’s stated. One prequalification covers both — on this bid and the next.
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