National Institutes of HealthIssuing agency·Nationwide·via the Grants.gov Search APIThis Notice of Funding Opportunity (NOFO) invites applicants to support Testing Centers for Evaluation of Somatic Cell Genome Editing Approaches for Translational Applications. Each center will provide resources and testing services to the growing community, developing new genome editing technologies and conducting preclinical testing based on these technologies for therapeutics for human diseases. The testing centers will work with NIH-funded investigators to assess the efficacy and safety of genome editing and delivery technologies, determine genome editing thresholds for specific diseases associated with minimal off-target effects, and ascertain feasibility parameters in model systems. This NOFO is especially interested in the application of new approach methodologies (NAMs) to complement traditional in vivo models for the purposes described in this announcement.
Research Initiative Details
The Testing Centers will establish in vivo and in vitro research models applicable to human health and disease, including NAMs and human-biology-based models. The Testing Centers will develop assays and Standard Operating Procedures (SOPs) for evaluating new genome editing technologies. Data generated by the Centers will help determine whether a treatment strategy using a specific set of tools is effective, has an acceptable safety profile, or requires significant improvement in editing efficacy and specificity. Although each Testing Center will work on a limited number of focused projects, the program and pipeline(s) developed are expected to support multifaceted research activities, build core model systems that can be adapted to accommodate a broad spectrum of diseases, and provide fee-for-service resources to the wider biomedical community on a local, regional, and national basis.
The goal of projects supported by this NOFO is to provide research resources that facilitate optimization and enhance scientific rigor, transparency, and experimental reproducibility in biomedical research.
Each Testing Center will establish in vivo and in vitro research models applicable to human health and disease, including new approach methodologies (NAMs) and human-biology-based models. Centers will develop assays and Standard Operating Procedures (SOPs) for evaluating new genome editing technologies. Data generated will help determine whether a treatment strategy is effective, has an acceptable safety profile, or requires improvement. Centers will work on focused projects, build core model systems adaptable to a broad spectrum of diseases, and provide fee-for-service resources to the biomedical community.
We post new health & medical research opportunities as agencies publish them. Get them in one email — free, and unsubscribe whenever.
"07""Native American tribal governments (Federally recognized)""01""County governments""05""Independent school districts""02""City or township governments""25""Others (see text field entitled \"Additional Information on Eligibility\" for clarification)""12""Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education""11""Native American tribal organizations (other than Federally recognized tribal governments)""22""For profit organizations other than small businesses""23""Small businesses""20""Private institutions of higher education""08""Public housing authorities/Indian housing authorities""06""Public and State controlled institutions of higher education""13""Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education""00""State governments""04""Special district governments""CA""Cooperative Agreement""HL""Health"Most public work asks for the two below, and the solicitation documents are where it’s stated. One prequalification covers both — on this bid and the next.
A surety’s written statement that it expects to bond you up to a stated amount, subject to final underwriting. It’s what an agency asks to see before they take your bid seriously.
Source: Grants.gov (opportunity 364066), retrieved via the Grants.gov Search API. View the official posting, and always confirm requirements and deadlines with the issuing agency.