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The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. By achieving AI advantage, these teams will advance the DOE's mission and ensure America’s security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia. The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud.
DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions).
In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards. In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications.
"99""Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled \"Additional Information on Eligibility\"""O""Other""ST""Science and Technology and other Research and Development""SC""PAMS-SC""PAMS-SC""Office of Science""PAMS""PAMS""PAMS""PAMS""Department of Energy - Office of Science""PAMS"{"id":432260,"revision":1,"cfdaNumber":"81.049","programTitle":"Office of Science Financial Assistance Program","opportunityId":361526}{"revision":0,"opportunityId":361526}10"Y""Mar 17, 2026 05:22:41 PM EDT""U""PAMS-SC""50000""Mar 17, 2027 12:00:00 AM EDT"true"Mar 17, 2026 08:54:35 AM EDT""Mar 17, 2026 12:00:00 AM EDT""3750000""Dec 17, 2026 12:00:00 AM EST""<p><span class=\"ql-cursor\"></span> <span style=\"color: black;\">The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the </span><a href=\"https://www.energy.gov/documents/genesis-mission-science-and-technology-challenges?utm_medium=email&utm_source=govdelivery\" target=\"_blank\">Genesis Mission National Science and Technology Challenges</a><span style=\"color: black;\"> to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. By achieving AI advantage, these teams will advance the DOE's mission and ensure America’s security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia. The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud.</span></p> \n<p><span style=\"color: black;\"> </span></p> \n<p> <span style=\"color: black;\">DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in </span><a target=\"_blank\">Section III</a><span style=\"color: black;\"> Program Descriptions).</span></p> \n<p><span style=\"color: black;\"> </span></p> \n<p> <span style=\"color: black;\">In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards. In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications.</span></p>"{"code":"SC","seed":"PAMS-SC","agencyCode":"PAMS-SC","agencyName":"Office of Science","topAgencyCode":"PAMS"}361526[{"id":"99","description":"Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled \"Additional Information on Eligibility\""}]"2027-03-17-00-00-00""2026-03-17-00-00-00""Mar 17, 2026 09:06:03 AM EDT""Mar 17, 2026 08:54:35 AM EDT""2026-12-17-00-00-00""293760000""GenesisMissionNOFO@science.doe.gov""GenesisMissionNOFO@science.doe.gov""Michael S Zarkin\nGrants Management Specialist""GenesisMissionNOFO@science.doe.gov""301-903-4946""2026-03-17-09-06-03"[{"id":"O","description":"Other"}]"50,000""3,750,000""GenesisMissionNOFO@science.doe.gov""293,760,000"[{"id":"ST","description":"Science and Technology and other Research and Development"}]0361526"D""Discretionary"{"id":432260,"revision":1,"cfdaNumber":"81.049","programTitle":"Office of Science Financial Assistance Program","opportunityId":361526}{"revision":1,"opportunityId":361526}21"N""Apr 10, 2026 09:22:17 AM EDT""U""PAMS-SC""500000""Mar 17, 2027 12:00:00 AM EDT"true"Mar 17, 2026 08:54:35 AM EDT""typo correction""Mar 17, 2026 12:00:00 AM EDT""5000000""Dec 17, 2026 12:00:00 AM EST""<p><span style=\"color: black;\">The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the </span><a href=\"https://www.energy.gov/documents/genesis-mission-science-and-technology-challenges?utm_medium=email&utm_source=govdelivery\" target=\"_blank\">Genesis Mission National Science and Technology Challenges</a><span style=\"color: black;\"> to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. By achieving AI advantage, these teams will advance the DOE's mission and ensure America’s security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia. The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud.</span></p> \n<p><span style=\"color: black;\"> </span></p> \n<p><span style=\"color: black;\">DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in </span>Section III<span style=\"color: black;\"> Program Descriptions).</span></p> \n<p><span style=\"color: black;\"> </span></p> \n<p><span style=\"color: black;\">In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards. In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications.</span></p>"{"code":"SC","seed":"PAMS-SC","agencyCode":"PAMS-SC","agencyName":"Office of Science","topAgencyCode":"PAMS"}361526[{"id":"99","description":"Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled \"Additional Information on Eligibility\""}]"2027-03-17-00-00-00""2026-03-17-00-00-00""Apr 07, 2026 11:15:49 AM EDT""Mar 17, 2026 05:22:41 PM EDT""2026-12-17-00-00-00""293760000""GenesisMissionNOFO@science.doe.gov""GenesisMissionNOFO@science.doe.gov""Michael S Zarkin\nGrants Management Specialist""GenesisMissionNOFO@science.doe.gov""301-903-4946""2026-04-07-11-15-49"[{"id":"O","description":"Other"}]"500,000""5,000,000""GenesisMissionNOFO@science.doe.gov""293,760,000"[{"id":"ST","description":"Science and Technology and other Research and Development"}]1361526"D""Discretionary"{"id":350588,"fileName":"DE-FOA-0003612.000003.pdf","mimeType":"application/pdf","createdDate":"Mar 17, 2026 08:55:05 AM EDT","fileLobSize":1321107,"opportunityId":361526,"fileDescription":"DE-FOA-0003612","lastUpdatedDate":"Apr 20, 2026 05:28:00 PM EDT","synopsisAttFolderId":79005}{"id":350878,"fileName":"Sample OT and Project Agreements for DE-FOA-0003612.pdf","mimeType":"application/pdf","createdDate":"Mar 31, 2026 11:33:01 AM EDT","fileLobSize":1740181,"opportunityId":361526,"fileDescription":"Sample OT and Project Agreements","synopsisAttFolderId":79119}{"id":350589,"fileName":"Genesis Mission Phase I Application Template v2.xlsx","mimeType":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","createdDate":"Mar 17, 2026 09:05:41 AM EDT","fileLobSize":28058,"opportunityId":361526,"fileDescription":"Phase I Application Template","lastUpdatedDate":"Apr 10, 2026 09:23:28 AM EDT","synopsisAttFolderId":79006}{"id":351082,"fileName":"Genesis Mission Phase II Application Template.xlsx","mimeType":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","createdDate":"Apr 10, 2026 09:24:24 AM EDT","fileLobSize":35219,"opportunityId":361526,"fileDescription":"Phase II Application Template","synopsisAttFolderId":79006}{"id":350590,"fileName":"Genesis Mission Phase II LOI Template v2.xlsx","mimeType":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","createdDate":"Mar 17, 2026 09:06:03 AM EDT","fileLobSize":26515,"opportunityId":361526,"fileDescription":"Phase II LOI Template","lastUpdatedDate":"Apr 10, 2026 09:23:46 AM EDT","synopsisAttFolderId":79006}Source: Grants.gov (opportunity GRANTS-361526), retrieved via the Grants.gov Search API. 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