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This Notice of Funding Opportunity (NOFO) encourages grant applications for Animal and Biological Material Resource Centers. These Centers provide support for special colonies of laboratory animals and associated services, as well as other resources such as informatics tools, reagents, cultures (cells, tissues, and organs) and genetic stocks that serve the biomedical research community in a variety of research areas on a local, regional, and national basis. The goal of projects supported by this NOFO is to provide research resources that facilitate optimization and enhancement of scientific rigor, transparency, and experimental reproducibility of biomedical research. Proposed Animal and Biological Material Resource Centers must have broad application to multiple NIH Institutes or Centers (ICs) to align with the ORIP"s NIH-wide mission (https://orip.nih.gov/about-orip). This funding opportunity is designed to support both continuation of existing resources and to develop new ones when appropriate. Of special interest of the announcement is a requirement of the Center"s close coordination with efforts to develop new approach methodologies (NAMs) that complement traditional animal-based research. These include cell culture, organoids, computational models, and microphysiological systems. Applied Research Component should include studies to generate comparative data to increase applicability of NAMs and promote integration of the most predictive human disease models. Prior to preparing an application, all applicants are strongly encouraged to consult with Scientific/Research staff to be advised on appropriateness of the intended resource plans for this program, competitiveness of a potential application, and ORIP's program priorities.
"08""Public housing authorities/Indian housing authorities""00""State governments""01""County governments""20""Private institutions of higher education""12""Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education""07""Native American tribal governments (Federally recognized)""22""For profit organizations other than small businesses""05""Independent school districts""11""Native American tribal organizations (other than Federally recognized tribal governments)""23""Small businesses""06""Public and State controlled institutions of higher education""G""Grant""HL""Health""00""State governments""01""County governments""20""Private institutions of higher education""25""Others (see text field entitled \"Additional Information on Eligibility\" for clarification)""02""City or township governments""12""Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education""22""For profit organizations other than small businesses""13""Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education""23""Small businesses""04""Special district governments""06""Public and State controlled institutions of higher education""G""Grant""HL""Health""NIH""HHS-NIH11""HHS-NIH11""National Institutes of Health""HHS""HHS""HHS""HHS""Department of Health and Human Services""HHS"{"id":429509,"revision":3,"cfdaNumber":"93.351","programTitle":"Research Infrastructure Programs","opportunityId":359646}10{"revision":0,"opportunityId":359646}"Y""Dec 05, 2025 12:29:09 PM EST""U""HHS-NIH11"2027false"Jun 09, 2025 03:18:45 PM EDT""Jun 09, 2025 12:00:00 AM EDT""Dec 01, 2026 12:00:00 AM EST""<p>The Office of Research Infrastructure Programs at Division of Program Coordination, Planning and Strategic Initiatives intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to provide support for the Animal and Biological Material Resource Centers. The P40 mechanism supports projects to develop and maintain animal (mammalian and nonmammalian) models, related animal or biological material resources, and new approach methodologies (NAMs) available to all qualified investigators without regard to the scientific disciplines or disease orientations of their research activities or specifically directed to a categorical program.</p><p><br></p><p>This Notice is being provided now to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO will have nine application cycles. The NOFO is expected to be published in December 2025, with an expected application due date in February 2026. Details of the planned NOFO are provided below.</p><p><br></p><p><strong>Research Initiative Details</strong></p><p>With this intended reissue of the P40 funding opportunity, ORIP seeks to provide support for special colonies of laboratory animals and associated services, as well as other resources such as informatics tools, reagents, cultures (cells, tissues, and organs) and genetic stocks that serve the biomedical research community in a variety of research areas on a local, regional, and national basis.</p><p><br></p><p>The goal of projects supported by this NOFO is to provide research resources that facilitate optimization and enhancement of scientific rigor, transparency, and experimental reproducibility of biomedical research.</p><p><br></p><p>Collecting, generating, and distributing animal models and providing related services render these resources more accessible to the research community and eliminate costly redundant efforts. Of special interest of the announcement is a requirement of the Center’s close coordination with efforts to develop new approach methodologies (NAMS) that complement traditional animal-based research. These include cell culture, organoids, computational models, and microphysiological systems. Proposed resources should emphasize use of broadly applicable, interdisciplinary validation tools that enhance the predictive power of human disease models and support their integration with NAMs.</p><p><br></p><p>Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the P40 activity code. Investigators with expertise and insights into animal and non-animal models of human diseases are encouraged to begin to consider applying for this NOFO. In addition, collaborative investigations combining expertise in genetics and biology as well as research databases will be encouraged; these investigators should also begin considering applying for this application.</p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359646[{"id":"00","description":"State governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"01","description":"County governments"},{"id":"20","description":"Private institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"23","description":"Small businesses"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"05","description":"Independent school districts"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"07","description":"Native American tribal governments (Federally recognized)"}]"2""2025-06-09-00-00-00""Jun 09, 2025 03:19:16 PM EDT""2026-12-01-00-00-00""Jun 09, 2025 03:19:16 PM EDT""1300000""Oleg Mirochnitchenko, PhD\r\nOffice of Research Infrastructure Programs (ORIP)""Oleg.mirochnitchenko@nih.gov""301-435-0748""2025-06-09-15-19-16"[{"id":"G","description":"Grant"}]"Dec 11, 2026 12:00:00 AM EST""Oleg.mirochnitchenko@nih.gov""2026-12-11-00-00-00""Dec 18, 2025 12:00:00 AM EST""2025-12-18-00-00-00""1,300,000"[{"id":"HL","description":"Health"}]"Feb 18, 2026 12:00:00 AM EST""2026-02-18-00-00-00"0359646"D""Discretionary"{"id":429509,"revision":3,"cfdaNumber":"93.351","programTitle":"Research Infrastructure Programs","opportunityId":359646}22{"revision":2,"opportunityId":359646}"N""Dec 05, 2025 12:29:52 PM EST""U""HHS-NIH11"2027false"Jun 09, 2025 03:18:45 PM EDT""FON updated to reflect final NOFO prior to publication.""Jun 09, 2025 12:00:00 AM EDT""Dec 01, 2026 12:00:00 AM EST""<p>The Office of Research Infrastructure Programs at Division of Program Coordination, Planning and Strategic Initiatives intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to provide support for the Animal and Biological Material Resource Centers. The P40 mechanism supports projects to develop and maintain animal (mammalian and nonmammalian) models, related animal or biological material resources, and new approach methodologies (NAMs) available to all qualified investigators without regard to the scientific disciplines or disease orientations of their research activities or specifically directed to a categorical program.</p><p><br></p><p>This Notice is being provided now to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO will have nine application cycles. The NOFO is expected to be published in December 2025, with an expected application due date in February 2026. Details of the planned NOFO are provided below.</p><p><br></p><p><strong>Research Initiative Details</strong></p><p>With this intended reissue of the P40 funding opportunity, ORIP seeks to provide support for special colonies of laboratory animals and associated services, as well as other resources such as informatics tools, reagents, cultures (cells, tissues, and organs) and genetic stocks that serve the biomedical research community in a variety of research areas on a local, regional, and national basis.</p><p><br></p><p>The goal of projects supported by this NOFO is to provide research resources that facilitate optimization and enhancement of scientific rigor, transparency, and experimental reproducibility of biomedical research.</p><p><br></p><p>Collecting, generating, and distributing animal models and providing related services render these resources more accessible to the research community and eliminate costly redundant efforts. Of special interest of the announcement is a requirement of the Center’s close coordination with efforts to develop new approach methodologies (NAMS) that complement traditional animal-based research. These include cell culture, organoids, computational models, and microphysiological systems. Proposed resources should emphasize use of broadly applicable, interdisciplinary validation tools that enhance the predictive power of human disease models and support their integration with NAMs.</p><p><br></p><p>Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the P40 activity code. Investigators with expertise and insights into animal and non-animal models of human diseases are encouraged to begin to consider applying for this NOFO. In addition, collaborative investigations combining expertise in genetics and biology as well as research databases will be encouraged; these investigators should also begin considering applying for this application.</p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359646[{"id":"00","description":"State governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"01","description":"County governments"},{"id":"20","description":"Private institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"23","description":"Small businesses"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"05","description":"Independent school districts"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"07","description":"Native American tribal governments (Federally recognized)"}]"2""2025-06-09-00-00-00""Dec 05, 2025 12:29:09 PM EST""2026-12-01-00-00-00""Dec 05, 2025 12:29:09 PM EST""1300000""Oleg Mirochnitchenko, PhD\r\nOffice of Research Infrastructure Programs (ORIP)""Oleg.mirochnitchenko@nih.gov""301-435-0748""2025-12-05-12-29-09"[{"id":"G","description":"Grant"}]"Dec 11, 2026 12:00:00 AM EST""Oleg.mirochnitchenko@nih.gov""2026-12-11-00-00-00""Dec 18, 2025 12:00:00 AM EST""2025-12-18-00-00-00""1,300,000"[{"id":"HL","description":"Health"}]"Feb 18, 2026 12:00:00 AM EST""2026-02-18-00-00-00"2359646"D""Discretionary"{"id":429509,"revision":3,"cfdaNumber":"93.351","programTitle":"Research Infrastructure Programs","opportunityId":359646}{"id":431528,"revision":3,"opportunityId":359646}{"revision":3,"opportunityId":359646}13"Apr 16, 2026 10:00:43 AM EDT""U""HHS-NIH11""none""Feb 13, 2029 12:00:00 AM EST"false"Dec 05, 2025 12:29:52 PM EST""Dec 05, 2025 12:00:00 AM EST""none""Jan 09, 2029 12:00:00 AM EST""This Notice of Funding Opportunity (NOFO) encourages grant applications for Animal and Biological Material Resource Centers. These Centers provide support for special colonies of laboratory animals and associated services, as well as other resources such as informatics tools, reagents, cultures (cells, tissues, and organs) and genetic stocks that serve the biomedical research community in a variety of research areas on a local, regional, and national basis. The goal of projects supported by this NOFO is to provide research resources that facilitate optimization and enhancement of scientific rigor, transparency, and experimental reproducibility of biomedical research. Proposed Animal and Biological Material Resource Centers must have broad application to multiple NIH Institutes or Centers (ICs) to align with the ORIP\"s NIH-wide mission (https://orip.nih.gov/about-orip). This funding opportunity is designed to support both continuation of existing resources and to develop new ones when appropriate. Of special interest of the announcement is a requirement of the Center\"s close coordination with efforts to develop new approach methodologies (NAMs) that complement traditional animal-based research. These include cell culture, organoids, computational models, and microphysiological systems. Applied Research Component should include studies to generate comparative data to increase applicability of NAMs and promote integration of the most predictive human disease models. Prior to preparing an application, all applicants are strongly encouraged to consult with Scientific/Research staff to be advised on appropriateness of the intended resource plans for this program, competitiveness of a potential application, and ORIP's program priorities."{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359646[{"id":"00","description":"State governments"},{"id":"04","description":"Special district governments"},{"id":"13","description":"Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"01","description":"County governments"},{"id":"20","description":"Private institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"23","description":"Small businesses"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"02","description":"City or township governments"}]"2029-02-13-00-00-00""2""2025-12-05-00-00-00""Dec 05, 2025 12:30:03 PM EST""Dec 05, 2025 12:29:52 PM EST""2029-01-09-00-00-00""1300000""ORIPDCM@mail.nih.gov""Office of Research Infrastructure Programs (ORIP)\nORIPDCM@mail.nih.gov""National Institutes of Health""ORIPDCM@mail.nih.gov""301-402-2541""2025-12-05-12-30-03"[{"id":"G","description":"Grant"}]"ORIPDCM@mail.nih.gov""Refer to Section III. Eligibility Information for additional information on eligibility. Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.""1,300,000"[{"id":"HL","description":"Health"}]3359646"D""Discretionary"{"id":351257,"fileName":"RFA-OD-25-011-Revised-Full-Announcement.html","mimeType":"text/html;charset=UTF-8","createdDate":"Apr 16, 2026 10:00:56 AM EDT","fileLobSize":163975,"opportunityId":359646,"fileDescription":"RFA-OD-25-011-Revised-Full-Announcement.html","synopsisAttFolderId":79302}Source: Grants.gov (opportunity GRANTS-359646), retrieved via the Grants.gov Search API. View the official posting — always confirm requirements and deadlines with the issuing agency.
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