Federal Grant · Grants.gov · West Virginia

Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)

Due Jun 2, 2027·308 days left·General ConstructionView official posting ↗

Issuing agency

National Institutes of Health

Method

Grant

Description

The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to accelerate precision probiotic interventions. Specifically, this NOFO solicits R33 applications that will characterize person-specific features affecting probiotic responses to identify subgroups of probiotic responders and to enhance probiotic clinical outcomes. The ultimate goal of this NOFO is to identify, understand, and develop strategies to address barriers in precision probiotic therapies to account for the heterogenicity in humans that causes inconsistent probiotic responses.
This NOFO will support studies to assess the ability of the unique patterns of host biology (e.g., native microbiome, immune system, gender, diet, age, genetic background, lifestyle, and health history) that are correlated with probiotic usage to detect the improvement of probiotic responsiveness. Well-suited applications must offer rigorously designed mechanistic studies using relevant/innovative animal models or in human subjects. This NOFO is intended to support projects where potential host biological patterns that are correlated with probiotic usage have been identified, as demonstrated with supportive preliminary data, but require further mechanistic studies to test for their causality or predictability.
Applicants pursuing early-stage research to identify host biological patterns that may affect probiotic health outcomes should consider the companion (R61/R33) NOFO PAR-AT-24-XXX (TEMP-25412).

Contact

Name

National Institutes of Health

grantsinfo@nih.gov

Phone

301-402-2541

Full source recordfrom Grants.gov

Detail

356927

Ost

POSTED

Cfdas

Id: 424640
Cfda Number: 93.121
Program Title: Oral Diseases and Disorders Research
Opportunity Id: 356927

Id: 424639
Cfda Number: 93.213
Program Title: Research and Training in Complementary and Integrative Health
Opportunity Id: 356927

Id: 424642
Cfda Number: 93.313
Program Title: NIH Office of Research on Women's Health
Opportunity Id: 356927

Id: 424643
Cfda Number: 93.393
Program Title: Cancer Cause and Prevention Research
Opportunity Id: 356927

Id: 424641
Cfda Number: 93.866
Program Title: Aging Research
Opportunity Id: 356927

Id: 424644
Opportunity Id: 356927

Listed

Doc Type

synopsis

Flag2006

Revision

Synopsis

Version

Agency Code

HHS-NIH11

Agency Name

National Institutes of Health

Award Floor

none

Agency Phone

301-402-2541

Archive Date

Jul 08, 2027 12:00:00 AM EDT

Cost Sharing

Created Date

Oct 31, 2024 02:27:38 PM EDT

Posting Date

Oct 31, 2024 12:00:00 AM EDT

Award Ceiling

none

Response Date

Jun 02, 2027 12:00:00 AM EDT

Synopsis Desc

The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to accelerate precision probiotic interventions. Specifically, this NOFO solicits R33 applications that will characterize person-specific features affecting probiotic responses to identify subgroups of probiotic responders and to enhance probiotic clinical outcomes. The ultimate goal of this NOFO is to identify, understand, and develop strategies to address barriers in precision probiotic therapies to account for the heterogenicity in humans that causes inconsistent probiotic responses. This NOFO will support studies to assess the ability of the unique patterns of host biology (e.g., native microbiome, immune system, gender, diet, age, genetic background, lifestyle, and health history) that are correlated with probiotic usage to detect the improvement of probiotic responsiveness. Well-suited applications must offer rigorously designed mechanistic studies using relevant/innovative animal models or in human subjects. This NOFO is intended to support projects where potential host biological patterns that are correlated with probiotic usage have been identified, as demonstrated with supportive preliminary data, but require further mechanistic studies to test for their causality or predictability. Applicants pursuing early-stage research to identify host biological patterns that may affect probiotic health outcomes should consider the companion (R61/R33) NOFO PAR-AT-24-XXX (TEMP-25412).

Agency Details

Code: NIH
Seed: HHS-NIH11
Agency Code: HHS-NIH11
Agency Name: National Institutes of Health
Top Agency Code: HHS

Opportunity Id

356927

Applicant Types

Id: "23"
Description: "Small businesses"

Id: "06"
Description: "Public and State controlled institutions of higher education"

Id: "22"
Description: "For profit organizations other than small businesses"

Id: "11"
Description: "Native American tribal organizations (other than Federally recognized tribal governments)"

Id: "07"
Description: "Native American tribal governments (Federally recognized)"

Id: "08"
Description: "Public housing authorities/Indian housing authorities"

Id: "12"
Description: "Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"

Id: "04"
Description: "Special district governments"

Id: "13"
Description: "Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education"

Id: "02"
Description: "City or township governments"

Id: "00"
Description: "State governments"

Id: "01"
Description: "County governments"

Id: "05"
Description: "Independent school districts"

Id: "20"
Description: "Private institutions of higher education"

Id: "25"
Description: "Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"

Archive Date Str

2027-07-08-00-00-00

Posting Date Str

2024-10-31-00-00-00

Create Time Stamp

Oct 31, 2024 02:43:28 PM EDT

Last Updated Date

Oct 31, 2024 02:27:38 PM EDT

Response Date Str

2027-06-02-00-00-00

Top Agency Details

Code: HHS
Seed: HHS
Agency Code: HHS
Agency Name: Department of Health and Human Services
Top Agency Code: HHS

Agency Address Desc

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

Agency Contact Desc

NIH Grants Information grantsinfo@nih.gov

Agency Contact Name

National Institutes of Health

Agency Contact Email

grantsinfo@nih.gov

Agency Contact Phone

301-402-2541

Create Time Stamp Str

2024-10-31-14-43-28

Funding Desc Link Url

http://grants.nih.gov/grants/guide/pa-files/PAR-25-210.html

Funding Instruments

Id: "G"
Description: "Grant"

Funding Desc Link Desc

https://grants.nih.gov/grants/guide/pa-files/PAR-25-210.html

Agency Contact Email Desc

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

Applicant Eligibility Desc

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Funding Activity Categories

Id: "ED"
Description: "Education"

Id: "HL"
Description: "Health"

Draft Mode

Publisher Uid

85078724978857742224107944047325102090

Agency Details

Code: NIH
Seed: HHS-NIH11
Agency Code: HHS-NIH11
Agency Name: National Institutes of Health
Top Agency Code: HHS

Opportunity Pkgs

288344

Listed

Dialect

XFDL2.2

Family Id

Mimetype

application/pdf

Extension

pdf

Package Id

PKG00288344

Last Update

Oct 31, 2024 02:36:14 PM EDT

Closing Date

Jun 2, 2027

Contact Info

eRA Service Desk Monday to Friday 7 am to 8 pm ET http://grants.nih.gov/support/

Grace Period

Opening Date

May 2, 2025

Agency Details

Code: "NIH"
Seed: "HHS-NIH11"
Agency Code: "HHS-NIH11"
Agency Name: "National Institutes of Health"
Top Agency Code: "HHS"

Competition Id

FORMS-I

Closing Date Str

2027-06-02-00-00-00

Is Multi Project

Opening Date Str

2025-05-02-00-00-00

Topportunity Id

356927

Competition Title

Use for due dates on or after January 25, 2025

Opportunity Title

Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)

Owning Agency Code

HHS-NIH11

Top Agency Details

Code: "HHS"
Seed: "HHS"
Agency Code: "HHS"
Agency Name: "Department of Health and Human Services"
Top Agency Code: "HHS"

Opportunity Number

PAR-25-210

Electronic Required

Open To Applicant Type

Expected Application Size

Workspace Compatible Flag

Expected Application Count

100

Original Due Date

Jun 02, 2027 12:00:00 AM EDT

Assist Compatible

Opportunity Title

Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)

Owning Agency Code

HHS-NIH11

Top Agency Details

Code: HHS
Seed: HHS
Agency Code: HHS
Agency Name: Department of Health and Human Services
Top Agency Code: HHS

Forecast Hist Count

Opportunity Number

PAR-25-210

Syn Post Date In Past

Yes

Synopsis Hist Count

Opportunity Category

Category: D
Description: Discretionary

Synopsis Attachment Folders

Id: 75113
Folder Name: PAR-25-210
Folder Type: Full Announcement
Zip Lob Size: 448
Created Date: Oct 31, 2024 02:27:47 PM EDT
Opportunity Id: 356927
Last Updated Date: Oct 31, 2024 02:43:28 PM EDT
Synopsis Attachments: {"id":343726,"fileName":"PAR-25-210-Full-Announcement.html","mimeType":"text/html","createdDate":"Oct 31, 2024 02:43:28 PM EDT","fileLobSize":422,"opportunityId":356927,"fileDescription":"PAR-25-210 Full Announcement Text","synopsisAttFolderId":75113}

Id: 356927
Title: Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)
Agency: National Institutes of Health
Number: PAR-25-210
Doc Type: synopsis
Cfda List: 93.866, 93.313, 93.393, 93.213, 93.121
Open Date: 10/31/2024
Close Date: 06/02/2027
Opp Status: posted
Agency Code: HHS-NIH11

State By

gazetteer

Categorized By

llm-nc

Source: Grants.gov (opportunity GRANTS-356927), retrieved via the Grants.gov Search API. View the official posting — always confirm requirements and deadlines with the issuing agency.

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