Department of DefenseIssuing agency·Virginia·via the SAM.gov Get Opportunities APIRead the notice and its 13 attached documents and pull out the scope, the deadlines and what you have to submit.
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline.
The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy. Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level.
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"222032114""ARLINGTON""VA""USA""675 NORTH RANDOLPH STREET""DARPA-PS-26-129-Amendment-01.pdf"409161"file"".pdf""1""2026-08-21T17:27:31.897+00:00""46aafa59b2af4ca18604fdba965d1999""public""0""public""429e0f37c6b743bca625589f8f43bbc0""0"13"0""Attachment_D_Proposal_Inst_and_Vol_I_Template_Tech_and_Management_Amendment_1.docx"57576"file"".docx""1""2026-08-21T17:27:31.897+00:00""482201724e244617934bfbf6496ddb51""public""0""public""54b505f38f2e45469c8aa23840b59493""0"12"0""PENG_Amendment_1_Summary_of_Changes.docx"26422"file"".docx""1""2026-08-21T17:27:31.897+00:00""1e8a7292046d481e9e7c8bdf699f0242""public""0""public""a5094cd5940c44568abb919a8888679b""0"11"0""DARPA-PS-26-129.pdf"373527"file"".pdf""1""2026-08-07T15:37:55.926+00:00""b7cd8af387714e4daf4196f5f3ff4b2f""public""0""public""f73fa552d9cc40c0b56df6501c41485d""0"10"0""Attachment_I_Schedule_of_Milestones_and_Payments.xlsx"22571"file"".xlsx""1""2026-08-07T15:37:55.926+00:00""a927241c2b124022bb80a3de7ab1e4f1""public""0""public""40baeeeccdda4652badcaab563757ff9""0"9"0""Attachment_E_Proposal_Instructions_and_Volume_II_Template_Cost.docx"47533"file"".docx""1""2026-08-07T15:37:55.926+00:00""1ea9b0e32b8b4d599ca80d926a378d9c""public""0""public""eeefa584853140909ecb77f16405a5fe""0"8"0""Attachment_H_Task_Description_Document__TDD_.docx"37671"file"".docx""1""2026-08-07T15:37:55.926+00:00""87c9da0e2ae742c2a8fe2a0b9685e0ac""public""0""public""acac71396eb9405a83a9bec1d8ca8a93""0"7"0""Attachment_G_Model_Other_Transaction_for_Prototype.docx"96186"file"".docx""1""2026-08-07T15:37:55.926+00:00""0b261733ec75425684251003375e1ad1""public""0""public""797b76b2810649ca84525209aa8e54a6""0"6"0""Attachment_F_DARPA_Cost_Proposal_Spreadsheet.xlsx"131802"file"".xlsx""1""2026-08-07T15:37:55.926+00:00""70a81a0518cc448ab692da2bda9dced0""public""0""public""1364ecdd2c4b4ec0837fd295e3d20932""0"5"0""Attachment_D_Proposal_Instructions_and_Volume_I_Template_Technical_and_Management.docx"56989"file"".docx""1""2026-08-07T15:37:55.926+00:00""3d4fa9fd2c564ed8a727aafd4b62cd85""public""0""public""34ed619fb7b5460c8a76c6c790554246""0"4"0""Attachment_C_Proposal_Summary_Slide_Template.pptx"137915"file"".pptx""1""2026-08-07T15:37:55.926+00:00""e63e806591924f1d91065d2d547da18d""public""0""public""82c547eec4614804abad7b12ad7cb4ce""0"3"0""Attachment_B_Abstract_Instructions_and_Template.docx"44484"file"".docx""1""2026-08-07T15:37:55.926+00:00""f44f3c3394334996842f72192248d6d3""public""0""public""1322264237104c8683387b0753ae0bf3""0"2"0""Attachment_A_Abstract_Summary_Side.pptx"435176"file"".pptx""1""2026-08-07T15:37:55.926+00:00""088efa350eb4426a9cb44217b09294ce""public""0""public""76f4bda12ac54f22a7e8235539e60b35""0"1"0"Most Virginia work asks for the two below, and the solicitation documents are where it’s stated. Here’s what each costs through Light RFP if you need one.
Source: SAM.gov (notice 8d7bb66b691a4def9e7efe4d4345bb7a), retrieved via the SAM.gov Get Opportunities API. View the official posting, and always confirm requirements and deadlines with the issuing agency.