Federal · SAM.gov · Virginia

High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

Department of DefenseIssuing agency·Virginia·via the SAM.gov Get Opportunities API

25days left

Due Nov 5, 2026·Posted Oct 8, 2026

Prequalify For BondingBonding Prequal

AI takeaways

DARPA is soliciting proposals to develop an in-silico capability for mapping all protein-protein interactions, with utility demonstrated in identifying diagnostic and therapeutic targets for traumatic brain injury.
The place of performance is VA.
Abstracts are due November 5, 2026, at 3:00 PM ET; questions are due November 3, 2026; an Industry Day was held on September 25, 2026.
The procurement method is a Solicitation using a modified two-stage acquisition approach (Abstracts and Oral Proposal Package).
The program is structured as a 30-month program with a 12-month Phase 1 and an 18-month Phase 2; this solicitation is for Phase 1 only.
Multiple awards are anticipated, and the type of instrument that may be awarded is an Other Transaction for Research.
Requirement: Proposers must have a Unique Entity Identifier (UEI) number and must register in the System for Award Management (SAM).
Requirement: Awardees will be required to submit invoices for payment electronically via the Wide Area Work Flow (WAWF) module in the Procurement Integrated Enterprise Environment.
Requirement: The required CMMC level for this solicitation is CMMC Level 1 (Self-Assessment).
Requirement: Proposers must be determined to be responsible by the Agreements Officer and must not be suspended or debarred from award by the Federal Government.

Pre-bid: Sep 25
Term: 30-month program featuring…
Method: Solicitation
Documents: 7 files

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Contact the buyer

Dr. Abhishek Singharoy

hubble@darpa.milEmail

Location:

VA 222032114

Open in Maps ↗

Notice

98c034706e4b430281ead1c3497e9d72

DARPA-PA-27-01

Method

Solicitation

Duration

30-month program featuring a 12-month Phase 1, followed by an 18-month Phase 2

What this bid is asking for

AI-generated

Submit an abstract via DARPA's Broad Agency Announcement Tool (BAAT) by November 5, 2026.
If invited, submit an Oral Proposal Package (OPP) and participate in an oral presentation to DARPA.
Propose an Other Transaction (OT) for Research with fixed payable milestones for a 12-month Phase 1 effort.
Develop an in-silico capability for mapping all protein-protein interactions, with a strategy for scaling to a hypercatalog of 10 million interactions.

Posted Scope of Work

The Defense Advanced Research Projects Agency (DARPA) is soliciting proposals to develop an in-silico capability for mapping all protein-protein interactions. Utility of this capability will be demonstrated in identifying novel diagnostic and therapeutic targets within the interaction space underlying including traumatic brain injury.

Scope, read from the documentsAI-generated

Performers will develop an in-silico capability to map protein-protein interactions (PPIs) by creating a low-dimensional 'diffusive binding landscape' signature. In Phase 1, performers will capture an initial interactome for TBI-associated proteins, modeling ~100,000 PPIs over >10 conditions. In Phase 2, performers will scale to a PPI hypercatalog of 10 million unique interactions modeled over >50 unique cellular contexts, capturing stable dimers, transient interactions, multiprotein complexes, and biocondensate/domain formation. The work includes internal benchmarking, validation against government team datasets, and iterative refinement of PPI predictions.

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Documents

Download zip

DARPA-PA-27-01.pdfPDF

Preview Download

Attachment_B_DARPA-PA-26-10__Model_OT_for_Research_HUBBLE_20261008.docxDOCX

Preview Download

Attachment_F_Risk_Matrix_HUBBLE.pptxPPTX

Preview Download

Attachment_E_Task_Description_Document_HUBBLE.docxDOCX

Preview Download

Attachment_D_Schedule_Milestone_and_Payments.xlsxXLSX

Preview Download

Attachment_C_Cost_Proposal_Spreadsheet_HUBBLE.xlsxXLSX

Preview Download

Attachment_A_Abstract_Template_and_Instructions__Phase_1_.docxDOCX

Preview Download

Questions & answers

AI-generated

What is the due date for abstracts?

Abstracts are due November 5, 2026, at 3:00 PM ET.

What type of award instrument will be used?

The type of instrument that may be awarded is an Other Transaction for Research.

Who is the technical point of contact?

The technical point of contact is Dr. Abhishek Singharoy, DARPA/BTO.

What is the place of performance?

The place of performance is VA.

Full source recordEvery field SAM.gov published, untouched

Hit

98c034706e4b430281ead1c3497e9d72

Type

Code: o
Value: Solicitation

Type

opportunity

Award

Awardee

Title

High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

R Score

Is Active

Yes

Is Canceled

Publish Date

Oct 8, 2026

Descriptions

Content: The Defense Advanced Research Projects Agency (DARPA) is soliciting proposals to develop an in-silico capability for mapping all protein-protein interactions. Utility of this capability will be demonstrated in identifying novel diagnostic and therape
Last Modified Date: Oct 8, 2026

Modified Date

Oct 8, 2026

Response Date

Nov 5, 2026

Modifications

Count: 0

Response Time Zone

America/New_York

Response Date Actual

Nov 5, 2026

Solicitation Number

DARPA-PA-27-01

Organization Hierarchy

Code

9700

Name

DEPT OF DEFENSE

Type

DEPARTMENT

Level

Status

active

Address

Organization Id

100000000

Code

97AE

Name

DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)

Type

AGENCY

Level

Status

active

Address

Organization Id

300000412

Code

HR0011

Name

DEF ADVANCED RESEARCH PROJECTS AGCY

Type

OFFICE

Level

Status

active

Address

Zip: "222032114"
City: "ARLINGTON"
State: "VA"
Country: "USA"
Street Address: "675 NORTH RANDOLPH STREET"

Organization Id

500035490

Org

Cgac

097

Code

HR0011

Name

DEF ADVANCED RESEARCH PROJECTS AGCY

Type

OFFICE

Level

L1 Name

DEPT OF DEFENSE

L2 Name

DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)

L3 Name

DEF ADVANCED RESEARCH PROJECTS AGCY

Org Key

500035490

Aac Code

HR0011

Fpds Code

97AE

L1 Org Key

100000000

L2 Org Key

300000412

Created By

MIGRATOR_NEW_ATOM_FEED

Fpds Org Id

HR0011

Mod Status

ACTIVE

Parent Org

DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)

Start Date

Oct 1, 2003

Created Date

May 2, 2004

L1 Short Name

DOD

Has Contracts

Yes

Is Source Fpds

Yes

Org Addresses

City: ARLINGTON
Type: M
State: VA
Org Key: 500035490
Zipcode: 222032114
Created By: MIGRATOR_NEW_ATOM_FEED
Mod Status: active
Address Key: 500668784
Country Code: USA
Created Date: May 2, 2004
Is Source Fpds: Yes
Street Address: 675 NORTH RANDOLPH STREET
Last Modified By: FPDSADMIN
Last Modified Date: Sep 17, 2013

Parent Org Key

300000412

Code Hierarchy

9700.97AE.HR0011

Org Legacy List

Source: LEGACY_OFFICES_FBO_DOD.xls
Org Key: 500035490
Legacy Id: 2597447818538ac164e1401b140bbb6e
Created By: nithin.john-emanuel@gsa.gov_oda
Legacy Key: 6731
Legacy Name: Contracts Management Office
Created Date: Oct 16, 2019
Last Modified By: nithin.john-emanuel@gsa.gov_oda
Last Modified Date: Oct 16, 2019
Legacy System Name: FBO

Full Parent Path

100000000.300000412.500035490

Last Modified By

FPDSADMIN_NEW_ATOM_FEED

Org Office Types

Org Key: 500035490
Position: 3
Is Latest: Yes
Office Id: 2135377
Created By: FH-RE-INGESTION
Mod Status: Yes
Start Date: Oct 1, 2003
Office Type: 1
Created Date: Jul 13, 2020
Office Type Id: 1
Last Modified By: FH-RE-INGESTION
Office Type Name: CONTRACT FUNDING
Last Modified Date: Jul 13, 2020

Org Key: 500035490
Position: 4
Is Latest: Yes
Office Id: 2135378
Created By: FH-RE-INGESTION
Mod Status: Yes
Start Date: Oct 1, 2003
Office Type: 5
Created Date: Jul 13, 2020
Office Type Id: 5
Last Modified By: FH-RE-INGESTION
Office Type Name: FINANCIAL ASSISTANCE FUNDING
Last Modified Date: Jul 13, 2020

Org Key: 500035490
Position: 1
Is Latest: Yes
Office Id: 2135379
Created By: FH-RE-INGESTION
Mod Status: Yes
Start Date: Oct 1, 2003
Office Type: 2
Created Date: Jul 13, 2020
Office Type Id: 2
Last Modified By: FH-RE-INGESTION
Office Type Name: CONTRACT AWARDS
Last Modified Date: Jul 13, 2020

Org Key: 500035490
Position: 2
Is Latest: Yes
Office Id: 2135376
Created By: FH_Job
Mod Status: Yes
Start Date: Oct 1, 2003
Office Type: 3
Created Date: Sep 30, 2018
Office Type Id: 3
Last Modified By: IAE_29337_DOD
Office Type Name: FINANCIAL ASSISTANCE AWARDS
Last Modified Date: Jan 8, 2020

Last Modified Date

Sep 17, 2013

Full Parent Path Name

DEPT OF DEFENSE.DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA).DEF ADVANCED RESEARCH PROJECTS AGCY

Type

Solicitation

Title

High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

Active

Yes

Detail

Type

Naics

Code: 541714
Type: primary

Title

High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

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Due after award

Flat 3%Get this one →

$0, forever48-hr responseA-ratedSoft pull

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Source: SAM.gov (notice 98c034706e4b430281ead1c3497e9d72), retrieved via the SAM.gov Get Opportunities API. View the official posting, and always confirm requirements and deadlines with the issuing agency.

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Federal · SAM.gov · Virginia

High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

Department of DefenseIssuing agency·Virginia·via the SAM.gov Get Opportunities API

25days left

Due Nov 5, 2026·Posted Oct 8, 2026

Prequalify For BondingBonding Prequal

AI takeaways

DARPA is soliciting proposals to develop an in-silico capability for mapping all protein-protein interactions, with utility demonstrated in identifying diagnostic and therapeutic targets for traumatic brain injury.
The place of performance is VA.
Abstracts are due November 5, 2026, at 3:00 PM ET; questions are due November 3, 2026; an Industry Day was held on September 25, 2026.
The procurement method is a Solicitation using a modified two-stage acquisition approach (Abstracts and Oral Proposal Package).
The program is structured as a 30-month program with a 12-month Phase 1 and an 18-month Phase 2; this solicitation is for Phase 1 only.
Multiple awards are anticipated, and the type of instrument that may be awarded is an Other Transaction for Research.
Requirement: Proposers must have a Unique Entity Identifier (UEI) number and must register in the System for Award Management (SAM).
Requirement: Awardees will be required to submit invoices for payment electronically via the Wide Area Work Flow (WAWF) module in the Procurement Integrated Enterprise Environment.
Requirement: The required CMMC level for this solicitation is CMMC Level 1 (Self-Assessment).
Requirement: Proposers must be determined to be responsible by the Agreements Officer and must not be suspended or debarred from award by the Federal Government.

Pre-bid: Sep 25
Term: 30-month program featuring…
Method: Solicitation
Documents: 7 files

These takeaways are AI-generated and may be incomplete or wrong. Always verify every detail against the official documents before you bid.

Want to know if you can be bonded for this project? Get prequalified.One free application, soft pull — sized to your work.

Know you can be bonded before you spend a week on the bid
No scramble for a bond at the deadline — it becomes a request form
A good guy letter to show an agency

Prequalify For Bonding →

Contact the buyer

Dr. Abhishek Singharoy

hubble@darpa.milEmail

Location:

VA 222032114

Open in Maps ↗

Notice

98c034706e4b430281ead1c3497e9d72

DARPA-PA-27-01

Method

Solicitation

Duration

30-month program featuring a 12-month Phase 1, followed by an 18-month Phase 2

What this bid is asking for

AI-generated

Submit an abstract via DARPA's Broad Agency Announcement Tool (BAAT) by November 5, 2026.
If invited, submit an Oral Proposal Package (OPP) and participate in an oral presentation to DARPA.
Propose an Other Transaction (OT) for Research with fixed payable milestones for a 12-month Phase 1 effort.
Develop an in-silico capability for mapping all protein-protein interactions, with a strategy for scaling to a hypercatalog of 10 million interactions.

Posted Scope of Work

Scope, read from the documentsAI-generated

More science & technology research bids in Virginia, weekly.

We post new science & technology research opportunities in Virginia as agencies publish them. Get them in one email — free, and unsubscribe whenever.

Documents

Download zip

DARPA-PA-27-01.pdfPDF

Preview Download

Attachment_B_DARPA-PA-26-10__Model_OT_for_Research_HUBBLE_20261008.docxDOCX

Preview Download

Attachment_F_Risk_Matrix_HUBBLE.pptxPPTX

Preview Download

Attachment_E_Task_Description_Document_HUBBLE.docxDOCX

Preview Download

Attachment_D_Schedule_Milestone_and_Payments.xlsxXLSX

Preview Download

Attachment_C_Cost_Proposal_Spreadsheet_HUBBLE.xlsxXLSX

Preview Download

Attachment_A_Abstract_Template_and_Instructions__Phase_1_.docxDOCX

Preview Download

Questions & answers

AI-generated

What is the due date for abstracts?

Abstracts are due November 5, 2026, at 3:00 PM ET.

What type of award instrument will be used?

The type of instrument that may be awarded is an Other Transaction for Research.

Who is the technical point of contact?

The technical point of contact is Dr. Abhishek Singharoy, DARPA/BTO.

What is the place of performance?

The place of performance is VA.

Full source recordEvery field SAM.gov published, untouched

Hit

98c034706e4b430281ead1c3497e9d72

Type

Code: o
Value: Solicitation

Type

opportunity

Award

Awardee

Title

High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

R Score

Is Active

Yes

Is Canceled

Publish Date

Oct 8, 2026

Descriptions

Content: The Defense Advanced Research Projects Agency (DARPA) is soliciting proposals to develop an in-silico capability for mapping all protein-protein interactions. Utility of this capability will be demonstrated in identifying novel diagnostic and therape
Last Modified Date: Oct 8, 2026

Modified Date

Oct 8, 2026

Response Date

Nov 5, 2026

Modifications

Count: 0

Response Time Zone

America/New_York

Response Date Actual

Nov 5, 2026

Solicitation Number

DARPA-PA-27-01

Organization Hierarchy

Code

9700

Name

DEPT OF DEFENSE

Type

DEPARTMENT

Level

Status

active

Address

Organization Id

100000000

Code

97AE

Name

DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)

Type

AGENCY

Level

Status

active

Address

Organization Id

300000412

Code

HR0011

Name

DEF ADVANCED RESEARCH PROJECTS AGCY

Type

OFFICE

Level

Status

active

Address

Zip: "222032114"
City: "ARLINGTON"
State: "VA"
Country: "USA"
Street Address: "675 NORTH RANDOLPH STREET"

Organization Id

500035490

Org

Cgac

097

Code

HR0011

Name

DEF ADVANCED RESEARCH PROJECTS AGCY

Type

OFFICE

Level

L1 Name

DEPT OF DEFENSE

L2 Name

DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)

L3 Name

DEF ADVANCED RESEARCH PROJECTS AGCY

Org Key

500035490

Aac Code

HR0011

Fpds Code

97AE

L1 Org Key

100000000

L2 Org Key

300000412

Created By

MIGRATOR_NEW_ATOM_FEED

Fpds Org Id

HR0011

Mod Status

ACTIVE

Parent Org

DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)

Start Date

Oct 1, 2003

Created Date

May 2, 2004

L1 Short Name

DOD

Has Contracts

Yes

Is Source Fpds

Yes

Org Addresses

City: ARLINGTON
Type: M
State: VA
Org Key: 500035490
Zipcode: 222032114
Created By: MIGRATOR_NEW_ATOM_FEED
Mod Status: active
Address Key: 500668784
Country Code: USA
Created Date: May 2, 2004
Is Source Fpds: Yes
Street Address: 675 NORTH RANDOLPH STREET
Last Modified By: FPDSADMIN
Last Modified Date: Sep 17, 2013

Parent Org Key

300000412

Code Hierarchy

9700.97AE.HR0011

Org Legacy List

Source: LEGACY_OFFICES_FBO_DOD.xls
Org Key: 500035490
Legacy Id: 2597447818538ac164e1401b140bbb6e
Created By: nithin.john-emanuel@gsa.gov_oda
Legacy Key: 6731
Legacy Name: Contracts Management Office
Created Date: Oct 16, 2019
Last Modified By: nithin.john-emanuel@gsa.gov_oda
Last Modified Date: Oct 16, 2019
Legacy System Name: FBO

Full Parent Path

100000000.300000412.500035490

Last Modified By

FPDSADMIN_NEW_ATOM_FEED

Org Office Types

Org Key: 500035490
Position: 3
Is Latest: Yes
Office Id: 2135377
Created By: FH-RE-INGESTION
Mod Status: Yes
Start Date: Oct 1, 2003
Office Type: 1
Created Date: Jul 13, 2020
Office Type Id: 1
Last Modified By: FH-RE-INGESTION
Office Type Name: CONTRACT FUNDING
Last Modified Date: Jul 13, 2020

Org Key: 500035490
Position: 4
Is Latest: Yes
Office Id: 2135378
Created By: FH-RE-INGESTION
Mod Status: Yes
Start Date: Oct 1, 2003
Office Type: 5
Created Date: Jul 13, 2020
Office Type Id: 5
Last Modified By: FH-RE-INGESTION
Office Type Name: FINANCIAL ASSISTANCE FUNDING
Last Modified Date: Jul 13, 2020

Org Key: 500035490
Position: 1
Is Latest: Yes
Office Id: 2135379
Created By: FH-RE-INGESTION
Mod Status: Yes
Start Date: Oct 1, 2003
Office Type: 2
Created Date: Jul 13, 2020
Office Type Id: 2
Last Modified By: FH-RE-INGESTION
Office Type Name: CONTRACT AWARDS
Last Modified Date: Jul 13, 2020

Org Key: 500035490
Position: 2
Is Latest: Yes
Office Id: 2135376
Created By: FH_Job
Mod Status: Yes
Start Date: Oct 1, 2003
Office Type: 3
Created Date: Sep 30, 2018
Office Type Id: 3
Last Modified By: IAE_29337_DOD
Office Type Name: FINANCIAL ASSISTANCE AWARDS
Last Modified Date: Jan 8, 2020

Last Modified Date

Sep 17, 2013

Full Parent Path Name

DEPT OF DEFENSE.DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA).DEF ADVANCED RESEARCH PROJECTS AGCY

Type

Solicitation

Title

High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

Active

Yes

Detail

Type

Naics

Code: 541714
Type: primary

Title

High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

Need a bond for this one? Get prequalified once.

Most Virginia work asks for the two below, and the solicitation documents are where it’s stated. One prequalification covers both — on this bid and the next.

Bid BondUsually 5–10% of your bid

Due with your bid

FreeGet this one →

Performance & Payment BondUsually 100% of the contract

Due after award

Flat 3%Get this one →

$0, forever48-hr responseA-ratedSoft pull

What’s a good guy letter?

A surety’s written statement that it expects to bond you up to a stated amount, subject to final underwriting. It’s what an agency asks to see before they take your bid seriously.

Bonding Directory Get a free bid bond

Not the right RFP for you?

Open opportunities in the same trade and area, with time left to bid

See all Science & Technology Research bids →

Not finding it?Describe the work in your own words and we’ll search the whole site.Search with AI →

Prequalify For Bondingknow you’re bondable · no bond scramble Bid bond

High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

What this bid is asking for

Posted Scope of Work

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Documents

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Questions & answers

Need a bond for this one? Get prequalified once.

Not the right RFP for you?

High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

What this bid is asking for

Posted Scope of Work

More science & technology research bids in Virginia, weekly.

Documents

Sign up for a Light RFP account to download documents

Questions & answers

Need a bond for this one? Get prequalified once.

Not the right RFP for you?