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This Notice of Funding Opportunity (NOFO) invites applications for a Research Coordinating Center (RCC) to participate in a consortium of clinical centers that will test anti-obesity medication (AOM) treatment strategies for youth with obesity that maximize benefits and minimize risks of AOM use. Such intervention strategies should support the promotion of healthy growth and development; adequate nutritional status/intake, healthy eating and physical activity behaviors; mental health and well-being (e.g., body image, self-esteem, mood, etc.), and quality of life and be feasible to implement in clinical care settings. Priority areas include testing strategies to determine optimal developmental stage for AOM initiation, rate and amount of weight loss, AOM class, dose, frequency, and duration, and content and intensity of adjunct lifestyle therapies that may be imperative to ensure normal psychological and physical development and to potentially avoid lifelong dependence on AOMs.
Investigators should also evaluate potential predictors of response/ nonresponse to various treatment strategies under evaluation. The clinical centers may conduct independent or multicenter trials but will collaborate on the development of protocols, use of common measures and data elements, use of a central laboratory and standardized procedures to collect data and biospecimens, and data analyses and manuscriptsThe RCC will lead, manage, and harmonize efforts for the Consortium including 1) providing management and administrative support; 2) providing leadership and expertise on statistical design and analysis, 3) providing research coordination with a central laboratory, 4) harmonizing data collection methods and use of common data elements, 5) developing the database; 6) conducting data management and data analyses for Consortium studies; and 7) fostering research collaborations. This NOFO uses a cooperative agreement mechanism (U24) and runs in parallel with a companion NOFO (RFA-DK-27-121).
The RCC will lead, manage, and harmonize efforts for the Consortium including: 1) providing management and administrative support; 2) providing leadership and expertise on statistical design and analysis; 3) providing research coordination with a central laboratory; 4) harmonizing data collection methods and use of common data elements; 5) developing the database; 6) conducting data management and data analyses for Consortium studies; and 7) fostering research collaborations. Priority areas include testing strategies to determine optimal developmental stage for AOM initiation, rate and amount of weight loss, AOM class, dose, frequency, and duration, and content and intensity of adjunct lifestyle therapies. Investigators should also evaluate potential predictors of response/nonresponse to various treatment strategies.
"23""Small businesses""11""Native American tribal organizations (other than Federally recognized tribal governments)""25""Others (see text field entitled \"Additional Information on Eligibility\" for clarification)""02""City or township governments""22""For profit organizations other than small businesses""07""Native American tribal governments (Federally recognized)""00""State governments""01""County governments""05""Independent school districts""08""Public housing authorities/Indian housing authorities""04""Special district governments""06""Public and State controlled institutions of higher education""20""Private institutions of higher education""12""Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education""CA""Cooperative Agreement""HL""Health""23""Small businesses""11""Native American tribal organizations (other than Federally recognized tribal governments)""25""Others (see text field entitled \"Additional Information on Eligibility\" for clarification)""02""City or township governments""22""For profit organizations other than small businesses""07""Native American tribal governments (Federally recognized)""00""State governments""13""Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education""01""County governments""05""Independent school districts""08""Public housing authorities/Indian housing authorities""04""Special district governments""06""Public and State controlled institutions of higher education""20""Private institutions of higher education""12""Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education""CA""Cooperative Agreement""HL""Health""NIH""HHS-NIH11""HHS-NIH11""National Institutes of Health""HHS""HHS""HHS""HHS""Department of Health and Human Services""HHS"{"id":430909,"revision":1,"cfdaNumber":"93.847","programTitle":"Diabetes, Digestive, and Kidney Diseases Extramural Research","opportunityId":360441}10{"revision":0,"opportunityId":360441}"Jun 08, 2026 02:33:54 PM EDT""U""HHS-NIH11"2027false"Sep 02, 2025 12:40:35 PM EDT""Sep 02, 2025 12:00:00 AM EDT""Jul 01, 2027 12:00:00 AM EDT""<p style=\"margin-left:0px;\">This Notice of Funding Opportunity (NOFO) invites applications for a Research Coordinating Center (RCC) for<strong> </strong>a consortium of clinical centers that will test anti-obesity medication (AOM) treatment strategies for youth with obesity to maximize benefits and minimize risks of AOM use. Priority areas include testing strategies to determine optimal developmental stage for AOM initiation, rate and amount of weight loss, AOM class, dose, frequency, and duration, and content and intensity of adjunct lifestyle therapies that may be imperative to ensure normal psychological and physical development and to potentially avoid lifelong dependence on AOMs. Investigators should also evaluate potential predictors of response/ nonresponse to various treatment strategies under evaluation. </p><p style=\"margin-left:0px;\"> </p><p style=\"margin-left:0px;\">The consortium may conduct independent or multicenter trials but will collaborate on the development of protocols, use of common measures and data elements, use of a central laboratory and standardized procedures to collect data and biospecimens, and data analyses and manuscripts. The RCC will lead, manage, and harmonize efforts for the Consortium including 1) providing management and administrative support; 2) providing leadership and expertise on statistical design and analysis, 3) providing research coordination with a central laboratory, harmonizing data collection methods and common data elements, data management and data analyses for Consortium studies; and 4) fostering research collaborations. </p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}360441[{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"04","description":"Special district governments"},{"id":"20","description":"Private institutions of higher education"},{"id":"00","description":"State governments"},{"id":"01","description":"County governments"},{"id":"05","description":"Independent school districts"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"02","description":"City or township governments"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"23","description":"Small businesses"}]"1""2025-09-02-00-00-00""Sep 02, 2025 12:40:35 PM EDT""2027-07-01-00-00-00""Sep 02, 2025 12:40:35 PM EDT""Stavroula K. Osganian, MD, ScD, MPH""voula.osganian@nih.gov""(301) 827-6939""2025-09-02-12-40-35"[{"id":"CA","description":"Cooperative Agreement"}]"Jul 01, 2027 12:00:00 AM EDT""voula.osganian@nih.gov""2027-07-01-00-00-00""Apr 01, 2026 12:00:00 AM EDT""Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).""2026-04-01-00-00-00"[{"id":"HL","description":"Health"}]"Dec 01, 2026 12:00:00 AM EST""2026-12-01-00-00-00"0360441"D""Discretionary"{"id":430909,"revision":1,"cfdaNumber":"93.847","programTitle":"Diabetes, Digestive, and Kidney Diseases Extramural Research","opportunityId":360441}22{"revision":2,"opportunityId":360441}"Jun 08, 2026 02:33:54 PM EDT""U""HHS-NIH11"2027false"Sep 02, 2025 12:40:35 PM EDT""Sep 02, 2025 12:00:00 AM EDT""Jul 01, 2027 12:00:00 AM EDT""<p style=\"margin-left:0px;\">This Notice of Funding Opportunity (NOFO) invites applications for a Research Coordinating Center (RCC) for<strong> </strong>a consortium of clinical centers that will test anti-obesity medication (AOM) treatment strategies for youth with obesity to maximize benefits and minimize risks of AOM use. Priority areas include testing strategies to determine optimal developmental stage for AOM initiation, rate and amount of weight loss, AOM class, dose, frequency, and duration, and content and intensity of adjunct lifestyle therapies that may be imperative to ensure normal psychological and physical development and to potentially avoid lifelong dependence on AOMs. Investigators should also evaluate potential predictors of response/ nonresponse to various treatment strategies under evaluation. </p><p style=\"margin-left:0px;\"> </p><p style=\"margin-left:0px;\">The consortium may conduct independent or multicenter trials but will collaborate on the development of protocols, use of common measures and data elements, use of a central laboratory and standardized procedures to collect data and biospecimens, and data analyses and manuscripts. The RCC will lead, manage, and harmonize efforts for the Consortium including 1) providing management and administrative support; 2) providing leadership and expertise on statistical design and analysis, 3) providing research coordination with a central laboratory, harmonizing data collection methods and common data elements, data management and data analyses for Consortium studies; and 4) fostering research collaborations. </p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}360441[{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"},{"id":"04","description":"Special district governments"},{"id":"20","description":"Private institutions of higher education"},{"id":"00","description":"State governments"},{"id":"01","description":"County governments"},{"id":"05","description":"Independent school districts"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"02","description":"City or township governments"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"25","description":"Others (see text field entitled \"Additional Information on Eligibility\" for clarification)"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"23","description":"Small businesses"}]"1""2025-09-02-00-00-00""Jun 08, 2026 02:33:54 PM EDT""2027-07-01-00-00-00""Jun 08, 2026 02:33:54 PM EDT""Stavroula K. Osganian, MD, ScD, MPH""voula.osganian@nih.gov""(301) 827-6939""2026-06-08-14-33-54"[{"id":"CA","description":"Cooperative Agreement"}]"Jul 01, 2027 12:00:00 AM EDT""voula.osganian@nih.gov""2027-07-01-00-00-00""Apr 01, 2026 12:00:00 AM EDT""Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).""2026-04-01-00-00-00"[{"id":"HL","description":"Health"}]"Dec 01, 2026 12:00:00 AM EST""2026-12-01-00-00-00"2360441"D""Discretionary"{"id":352842,"fileName":"RFA-DK-27-136-Full-Announcement.html","mimeType":"text/html;charset=UTF-8","createdDate":"Jun 08, 2026 02:34:09 PM EDT","fileLobSize":151977,"opportunityId":360441,"fileDescription":"RFA-DK-27-136-Full-Announcement.html","synopsisAttFolderId":80156}Source: Grants.gov (opportunity 360441), retrieved via the Grants.gov Search API. View the official posting , always confirm requirements and deadlines with the issuing agency.