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The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges.The purpose of this NOFO is to catalyze the translation of Artificial Intelligence (AI)-enabled, image-centered, multimodal CDS tools, developed as Software as a Medical Device, from training and testing of prototypes towards clinical applications that address unmet health challenges in precision medicine.
These projects are expected to have high potential for demonstrable, positive impact on patient outcomes and/or healthcare processes.
"00""State governments""08""Public housing authorities/Indian housing authorities""11""Native American tribal organizations (other than Federally recognized tribal governments)""07""Native American tribal governments (Federally recognized)""01""County governments""06""Public and State controlled institutions of higher education""20""Private institutions of higher education""12""Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education""22""For profit organizations other than small businesses""23""Small businesses""05""Independent school districts""CA""Cooperative Agreement""HL""Health""00""State governments""08""Public housing authorities/Indian housing authorities""11""Native American tribal organizations (other than Federally recognized tribal governments)""07""Native American tribal governments (Federally recognized)""02""City or township governments""05""Independent school districts""13""Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education""04""Special district governments""25""Others (see text field entitled \"Additional Information on Eligibility\" for clarification)""01""County governments""06""Public and State controlled institutions of higher education""20""Private institutions of higher education""12""Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education""22""For profit organizations other than small businesses""23""Small businesses""CA""Cooperative Agreement""HL""Health""NIH""HHS-NIH11""HHS-NIH11""National Institutes of Health""HHS""HHS""HHS""HHS""Department of Health and Human Services""HHS"{"id":429538,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359666}10{"revision":0,"opportunityId":359666}"Y""Sep 12, 2025 03:01:02 PM EDT""U""HHS-NIH11"2026false"Jun 10, 2025 10:12:42 AM EDT""Jun 10, 2025 12:00:00 AM EDT""Sep 01, 2026 12:00:00 AM EDT""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s</span><strong style=\"color: rgb(51, 51, 51);\"> Translating Model to Clinic initiative</strong><span style=\"color: rgb(51, 51, 51);\"> will use a biphasic mechanism to initially focus on rigorous AI model building through the retrospective analysis and testing of large, interoperable multimodal datasets, laying a robust foundation for improved diagnostic accuracy, prognostic prediction, or therapeutic guidance where current methods fall short. Projects demonstrating strong potential and model readiness will advance to evaluating the real-world clinical utility of the AI-driven Clinical Decision Support (CDS) tool. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into analysis and testing of large, interoperable multimodal datasets are encouraged to begin to consider applying for this new NOFO.</span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359666[{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"20","description":"Private institutions of higher education"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"23","description":"Small businesses"},{"id":"01","description":"County governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"05","description":"Independent school districts"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"00","description":"State governments"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"}]"2025-06-10-00-00-00""Jun 10, 2025 10:12:42 AM EDT""2026-09-01-00-00-00""Jun 10, 2025 10:12:42 AM EDT""10200000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2025-06-10-10-12-42"[{"id":"CA","description":"Cooperative Agreement"}]"Sep 01, 2026 12:00:00 AM EDT""ODPRIMED-AI@od.nih.gov""2026-09-01-00-00-00""Jul 01, 2025 12:00:00 AM EDT""2025-07-01-00-00-00""10,200,000"[{"id":"HL","description":"Health"}]"Nov 01, 2025 12:00:00 AM EDT""2025-11-01-00-00-00"0359666"D""Discretionary"{"id":429538,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359666}21{"revision":1,"opportunityId":359666}"Y""Jan 21, 2026 11:39:38 AM EST""U""HHS-NIH11"2027false"Jun 10, 2025 10:12:42 AM EDT""Updated all estimated due dates.""Jun 10, 2025 12:00:00 AM EDT""Dec 01, 2026 12:00:00 AM EST""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s</span><strong style=\"color: rgb(51, 51, 51);\"> Translating Model to Clinic initiative</strong><span style=\"color: rgb(51, 51, 51);\"> will use a biphasic mechanism to initially focus on rigorous AI model building through the retrospective analysis and testing of large, interoperable multimodal datasets, laying a robust foundation for improved diagnostic accuracy, prognostic prediction, or therapeutic guidance where current methods fall short. Projects demonstrating strong potential and model readiness will advance to evaluating the real-world clinical utility of the AI-driven Clinical Decision Support (CDS) tool. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into analysis and testing of large, interoperable multimodal datasets are encouraged to begin to consider applying for this new NOFO.</span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359666[{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"20","description":"Private institutions of higher education"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"23","description":"Small businesses"},{"id":"01","description":"County governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"05","description":"Independent school districts"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"00","description":"State governments"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"}]"2025-06-10-00-00-00""Sep 12, 2025 03:01:02 PM EDT""2026-12-01-00-00-00""Sep 12, 2025 03:01:02 PM EDT""10200000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2025-09-12-15-01-02"[{"id":"CA","description":"Cooperative Agreement"}]"Dec 01, 2026 12:00:00 AM EST""ODPRIMED-AI@od.nih.gov""2026-12-01-00-00-00""Dec 11, 2025 12:00:00 AM EST""2025-12-11-00-00-00""10,200,000"[{"id":"HL","description":"Health"}]"Feb 11, 2026 12:00:00 AM EST""2026-02-11-00-00-00"1359666"D""Discretionary"{"id":429538,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359666}32{"revision":2,"opportunityId":359666}"N""Jan 21, 2026 11:40:54 AM EST""U""HHS-NIH11"2027false"Jun 10, 2025 10:12:42 AM EDT""FON updated to reflect the anticipated NOFO.""Jun 10, 2025 12:00:00 AM EDT""Dec 01, 2026 12:00:00 AM EST""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s</span><strong style=\"color: rgb(51, 51, 51);\"> Translating Model to Clinic initiative</strong><span style=\"color: rgb(51, 51, 51);\"> will use a biphasic mechanism to initially focus on rigorous AI model building through the retrospective analysis and testing of large, interoperable multimodal datasets, laying a robust foundation for improved diagnostic accuracy, prognostic prediction, or therapeutic guidance where current methods fall short. Projects demonstrating strong potential and model readiness will advance to evaluating the real-world clinical utility of the AI-driven Clinical Decision Support (CDS) tool. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into analysis and testing of large, interoperable multimodal datasets are encouraged to begin to consider applying for this new NOFO.</span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359666[{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"20","description":"Private institutions of higher education"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"23","description":"Small businesses"},{"id":"01","description":"County governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"05","description":"Independent school districts"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"00","description":"State governments"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"}]"2025-06-10-00-00-00""Jan 21, 2026 11:39:38 AM EST""2026-12-01-00-00-00""Jan 21, 2026 11:39:38 AM EST""10200000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2026-01-21-11-39-38"[{"id":"CA","description":"Cooperative Agreement"}]"Dec 01, 2026 12:00:00 AM EST""ODPRIMED-AI@od.nih.gov""2026-12-01-00-00-00""Dec 11, 2025 12:00:00 AM EST""2025-12-11-00-00-00""10,200,000"[{"id":"HL","description":"Health"}]"Feb 11, 2026 12:00:00 AM EST""2026-02-11-00-00-00"2359666"D""Discretionary"{"id":429538,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359666}43{"revision":3,"opportunityId":359666}"Y""Jun 29, 2026 01:04:44 PM EDT""U""HHS-NIH11"2027false"Jun 10, 2025 10:12:42 AM EDT""Updated all estimated date fields.""Jun 10, 2025 12:00:00 AM EDT""Mar 01, 2027 12:00:00 AM EST""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s</span><strong style=\"color: rgb(51, 51, 51);\"> Translating Model to Clinic initiative</strong><span style=\"color: rgb(51, 51, 51);\"> will use a biphasic mechanism to initially focus on rigorous AI model building through the retrospective analysis and testing of large, interoperable multimodal datasets, laying a robust foundation for improved diagnostic accuracy, prognostic prediction, or therapeutic guidance where current methods fall short. Projects demonstrating strong potential and model readiness will advance to evaluating the real-world clinical utility of the AI-driven Clinical Decision Support (CDS) tool. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into analysis and testing of large, interoperable multimodal datasets are encouraged to begin to consider applying for this new NOFO.</span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359666[{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"20","description":"Private institutions of higher education"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"23","description":"Small businesses"},{"id":"01","description":"County governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"05","description":"Independent school districts"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"00","description":"State governments"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"}]"2025-06-10-00-00-00""Jan 21, 2026 11:40:54 AM EST""2027-03-01-00-00-00""Jan 21, 2026 11:40:54 AM EST""10200000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2026-01-21-11-40-54"[{"id":"CA","description":"Cooperative Agreement"}]"Mar 01, 2027 12:00:00 AM EST""ODPRIMED-AI@od.nih.gov""2027-03-01-00-00-00""Apr 17, 2026 12:00:00 AM EDT""2026-04-17-00-00-00""10,200,000"[{"id":"HL","description":"Health"}]"Jun 17, 2026 12:00:00 AM EDT""2026-06-17-00-00-00"3359666"D""Discretionary"{"id":429538,"revision":4,"cfdaNumber":"93.310","programTitle":"Trans-NIH Research Support","opportunityId":359666}55{"revision":5,"opportunityId":359666}"N""Jun 30, 2026 11:02:06 AM EDT""U""HHS-NIH11"2027false"Jun 10, 2025 10:12:42 AM EDT""Updated Opportunity Number and Title to match NOFO.""Jun 10, 2025 12:00:00 AM EDT""Mar 01, 2027 12:00:00 AM EST""<p><span style=\"color: rgb(51, 51, 51);\">The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the </span><strong style=\"color: rgb(51, 51, 51);\">Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks </strong><span style=\"color: rgb(51, 51, 51);\">to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s</span><strong style=\"color: rgb(51, 51, 51);\"> Translating Model to Clinic initiative</strong><span style=\"color: rgb(51, 51, 51);\"> will use a biphasic mechanism to initially focus on rigorous AI model building through the retrospective analysis and testing of large, interoperable multimodal datasets, laying a robust foundation for improved diagnostic accuracy, prognostic prediction, or therapeutic guidance where current methods fall short. Projects demonstrating strong potential and model readiness will advance to evaluating the real-world clinical utility of the AI-driven Clinical Decision Support (CDS) tool. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into analysis and testing of large, interoperable multimodal datasets are encouraged to begin to consider applying for this new NOFO.</span></p>"{"code":"NIH","seed":"HHS-NIH11","agencyCode":"HHS-NIH11","agencyName":"National Institutes of Health","topAgencyCode":"HHS"}359666[{"id":"07","description":"Native American tribal governments (Federally recognized)"},{"id":"20","description":"Private institutions of higher education"},{"id":"06","description":"Public and State controlled institutions of higher education"},{"id":"22","description":"For profit organizations other than small businesses"},{"id":"23","description":"Small businesses"},{"id":"01","description":"County governments"},{"id":"08","description":"Public housing authorities/Indian housing authorities"},{"id":"05","description":"Independent school districts"},{"id":"12","description":"Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education"},{"id":"00","description":"State governments"},{"id":"11","description":"Native American tribal organizations (other than Federally recognized tribal governments)"}]"2025-06-10-00-00-00""Jun 29, 2026 01:04:44 PM EDT""2027-03-01-00-00-00""Jun 29, 2026 01:04:44 PM EDT""10200000""Sahana N. Kukke, PhD \r\nOffice of the Director/NIH Common Fund, DPCPSI, OD""ODPRIMED-AI@od.nih.gov""301-402-3756""2026-06-29-13-04-44"[{"id":"CA","description":"Cooperative Agreement"}]"Mar 01, 2027 12:00:00 AM EST""ODPRIMED-AI@od.nih.gov""2027-03-01-00-00-00""Apr 17, 2026 12:00:00 AM EDT""2026-04-17-00-00-00""10,200,000"[{"id":"HL","description":"Health"}]"Jun 17, 2026 12:00:00 AM EDT""2026-06-17-00-00-00"5359666"D""Discretionary"{"id":353492,"fileName":"RFA-RM-27-013-Full-Announcement.html","mimeType":"text/html;charset=UTF-8","createdDate":"Jun 30, 2026 11:02:20 AM EDT","fileLobSize":177241,"opportunityId":359666,"fileDescription":"RFA-RM-27-013-Full-Announcement.html","synopsisAttFolderId":80537}Source: Grants.gov (opportunity 359666), retrieved via the Grants.gov Search API. View the official posting , always confirm requirements and deadlines with the issuing agency.